- Copilot AnswerStructure and function
PP2A consists of a dimeric core enzyme composed of the structural A and catalytic C subunits, and a regulatory B subunit. When the PP2A catalytic C subunit associates with the A and B subunits several spe… See more
Watch full videoDrug discoveryPP2 has been identified as a potential biological target to discover drugs to treat Parkinson's disease and Alzheimer's disease, however as of 2014 it was unclear which isoforms would be most beneficial to target, and … See more
Roles and regulation of protein phosphatase 2A (PP2A) …
PP2A plays a key role in regulation of cardiac excitability through dephosphorylation of cardiac ion channels, transporters, and their respective regulatory proteins.
Therapeutic Targeting of PP2A - PMC - PubMed …
Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase that regulates many cellular processes. Given the central role of PP2A in regulating diverse biological functions and its dysregulation in many diseases, including …
Protein phosphatase 2A: a target for anticancer therapy
Preclinical studies show that pharmacological restoration of PP2A tumour-suppressor activity by PP2A-activating drugs (eg, FTY720) effectively …
- Author: Danilo Perrotti, Paolo Neviani
- Publish Year: 2013
Phosphatase: PP2A structural importance, regulation and its …
This review is focused on the structural complexity of serine/threonine phosphatase PP2A and summarizes its expression pattern in cancer. Additionally, the PP2A interacting and regulatory …
Selective PP2A Enhancement through Biased …
Small molecules that activate the phosphatase PP2A (SMAPs) function by stabilizing the three subunits of the holoenzyme in a selective manner, thus …
- Author: Daniel Leonard, Daniel Leonard, Wei Huang, Sudeh Izadmehr, Caitlin M. O’Connor, Danica D. Wiredja, Z...
- Publish Year: 2020
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Protein phosphatase 2A in the healthy and failing heart: New …
Mar 1, 2022 · Protein phosphatases have emerged as critical regulators of phosphoprotein homeostasis in settings of health and disease. Protein phosphatase 2A (PP2A) encompasses …
Non-genomic mechanisms of protein phosphatase 2A (PP2A
Protein phosphatase 2A (PP2A) is a broad specificity serine/threonine phosphatase that functions as an antagonist of many signaling pathways associated with growth and proliferation, and …
Frontiers | Ppp2r2a Knockout Mice Reveal That Protein …
Jun 5, 2020 · The serine/threonine protein phosphatase 2A (PP2A) is a master regulator of the complex cellular signaling that occurs during all stages of mammalian development. PP2A is composed of a catalytic, a structural, and …
Protein phosphatase 2A - structure, function and role in ...
Jul 1, 2021 · This Review summarizes and discusses recent reports on NDDs associated with mutations of PP2A subunits and PP2A-associated proteins. We also discuss the potential …
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