- Protein phosphatase 2Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. [2][3] The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells. [4]en.wikipedia.org/wiki/Protein_phosphatase_2
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See all on WikipediaProtein phosphatase 2 - Wikipedia
Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells. Its serine/threonine phosphatase activity has a … See more
PP2A consists of a dimeric core enzyme composed of the structural A and catalytic C subunits, and a regulatory B subunit. When the PP2A catalytic C subunit associates with the A … See more
PP2 has been identified as a potential biological target to discover drugs to treat Parkinson's disease and Alzheimer's disease, however as of 2014 it was unclear which isoforms would be most beneficial to target, and also whether activation or … See more
• Seshacharyulu P, Pandey P, Datta K, Batra SK (July 2013). "Phosphatase: PP2A structural importance, regulation and its aberrant … See more
Wikipedia text under CC-BY-SA license PPP2CA Gene - GeneCards | PP2AA Protein | PP2AA …
Mar 30, 2025 · Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A is the …
Phosphatase: PP2A structural importance, regulation and its …
Protein Phosphatase 2A (PP2A) is an important and ubiquitously expressed serine threonine phosphatase and regulates the function by dephosphorylating many critical cellular molecules …
19052 - Gene ResultPpp2ca protein phosphatase 2 (formerly 2A ...
Feb 8, 2025 · Enables GABA receptor binding activity and protein serine/threonine phosphatase activity. Involved in T cell homeostasis; negative regulation of glycolytic process through …
Protein phosphatase 2A - structure, function and role in ...
Jul 1, 2021 · PP2A is responsible for at least 50% of total Ser/Thr dephosphorylation in most cell types and is predominantly found as trimeric holoenzymes composed of catalytic (C), …
- Author: Priyanka Sandal, Chian Ju Jong, Ronald A Merrill, Jianing Song, Stefan Strack
- Publish Year: 2021
Physiologic functions of PP2A: Lessons from genetically modified …
Jan 1, 2019 · Protein Phosphatase 2A (PP2A) encompasses a large family of Ser/Thr phosphatases, consisting of a catalytic C subunit and a structural A subunit that are, in most …
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Protein phosphatase 2A – structure, function and role …
Jul 6, 2021 · PP2A is responsible for at least 50% of total Ser/Thr dephosphorylation in most cell types and is predominantly found as trimeric holoenzymes composed of catalytic (C), scaffolding (A) and variable …
Roles and regulation of protein phosphatase 2A (PP2A) …
Protein phosphatase 2A (PP2A) is a central cardiac phosphatase that regulates diverse myocyte functions through a host of target molecules. Notably, multiple mechanisms have evolved to dynamically tune PP2A function, including …
Protein phosphatase 2A: a target for anticancer therapy
Unrestrained activation of oncogenic kinases together with inhibition of tumour suppressors is often required for development of cancer. PP2A has been shown to be genetically altered or functionally inactivated in many solid cancers and …
Protein phosphatase 2A: a highly regulated family of …
The use of specific PP2A inhibitors and molecular genetics in yeast, Drosophila and mice has revealed roles for PP2A in cell cycle regulation, cell morphology and development.
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