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Protein phosphatase 2A as a therapeutic target in …
Protein phosphatase 2A (PP2A) is a highly complex heterotrimeric enzyme that catalyzes the selective removal of phosphate groups from protein serine and threonine residues.
Targeting PP2A in cancer: Combination therapies - PMC
Protein Phosphatase 2A (PP2A) is a serine/threonine phosphatase with functions that counter-balance kinase-mediated phosphorylation throughout cell signaling networks. Its activity is critical to maintaining physiologic, ‘healthy’ cellular …
Therapeutic targeting of PP2A - PubMed
Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase that regulates many cellular processes. Given the central role of PP2A in regulating diverse biological functions …
- Author: Caitlin M. O’Connor, Abbey Perl, Daniel Leonard, Jaya Sangodkar, Goutham Narla
- Publish Year: 2018
Altering phosphorylation in cancer through PP2A modifiers
Jan 6, 2024 · In this review, we will discuss the patterns of PP2A deregulation in cancer, and its known downstream signaling pathways important for cancer regulation, along with many …
Protein phosphatase 2A: a target for anticancer therapy
Protein phosphatase 2A (PP2A), one of the main serine-threonine phosphatases in mammalian cells, maintains cell homoeostasis by counteracting most of the kinase-driven intracellular …
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Protein phosphatase 2A: a target for anticancer therapy
Preclinical studies show that pharmacological restoration of PP2A tumour-suppressor activity by PP2A-activating drugs (eg, FTY720) effectively …
- Author: Danilo Perrotti, Paolo Neviani
- Publish Year: 2013
A new regulatory mechanism of protein phosphatase 2A activity …
Jan 8, 2020 · PP2A phosphatase is a key regulator of cell homeostasis and is recurrently inactivated in AML. The anticancer activity of several PP2A-activating drugs (e.g., FTY720) …
- Author: Elena Arriazu, Elena Arriazu, Carmen Vicente, Raffaella Pippa, Raffaella Pippa, Irene Peris, Elena M...
- Publish Year: 2020
Targeting protein phosphatase PP2A for cancer therapy: …
These novel drugs promote the assembly of select heterotrimeric forms of PP2A that act to limit cell proliferation. We discuss the potential for the near-term translation of this approach to the …
PP2A Activating Drugs (PAD): Anti-Leukemic and Non-Toxic …
Nov 19, 2010 · FTY720 also acts as a potent activator of protein phosphatase 2A (PP2A), a tumor suppressor found inactivated in chronic and blast crisis CML with wild type or …
