Protein Phosphatase 2A (PP2A) is an important and ubiquitously expressed serine threonine phosphatase and regulates the function by dephosphorylating many critical cellular molecules …

In this review, we have compiled recent information about the function of protein phosphatases PP1, PP2A, PP4 and Cdc14 in the DDR, focusing mainly on their capacity to regulate the DNA …

Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase that regulates a diverse array of cellular processes. Here, utilizing both a gain-of-function chemical biology approach and …

May 27, 2024 · Conditions activating Snf1 AMPK rescue DDR functionality, but not NER, while inhibition of the TORC1-Sch9 S6K axis restores NER and enhances DDR by tuning PP2A …

Oct 1, 2022 · Here we discuss the known roles of protein phosphatases in replication initiation as part of cell cycle control and the DNA damage response. We highlight how dephosphorylation …

Oct 22, 2021 · PP2A is a major serine/threonine phosphatase class involved in the regulation of cell signaling through the removal of protein phosphorylation. This class of phosphatases is …

Jul 6, 2021 · One of the most abundant Ser/Thr phosphatases is protein phosphatase 2A (PP2A) (Clark and Ohlmeyer, 2019; Wlodarchak and Xing, 2016). PP2A is composed of a catalytic …

Dec 1, 2021 · PP2A mutants are sensitive to DNA replication stress without viability loss. PP2A is a primary phosphatase critical for cell cycle progression.

The serine/threonine phosphatase PP2A regulates a vast portion of the phosphoproteome including pathways involved in apoptosis, proliferation and DNA damage response and PP2A …

Jan 1, 2024 · CIP2A (cancerous inhibitor of PP2A) coordinately controls the essential characteristics of cancer cells such as protein phosphorylation, mitosis, and the DNA damage …