Oct 22, 2021 · PP2A-B55 upregulates the Wnt signaling pathway by dephosphorylating β-catenin and preventing its degradation. β-catenin directly binds PP2A-B55α and can be …

Dec 20, 2023 · Despite their critical roles in mitosis, the mechanisms by which they achieve PP2A:B55 inhibition is unknown. Here, we report the single-particle cryo-electron microscopy …

Oct 2, 2024 · The PP2A-B55 phosphatase regulates a plethora of signaling pathways throughout eukaryotes. How PP2A-B55 selects its substrates presents a severe knowledge gap. By …

Here, through the generation of loss-of-function genetic mouse models for the two ubiquitous B55 isoforms (B55α and B55δ), we report that PP2A-B55α and PP2A-B55δ complexes display …

In this study, we uncover an unexpected role of the PP2A phosphatase B55 SUR-6 in NEBD during the first embryonic division of Caenorhabditis elegans embryo. B55 SUR-6 depletion …

Aug 29, 2016 · PP2A-B55 is one of the major phosphatases regulating cell division. Despite its importance for temporal control during mitotic exit, how B55 substrates are recognized and …

The present review will focus on one specific heterocomplex, the phosphatase PP2A-B55. Herein, we will report the direct substrates of this phosphatase identified to date, and its impact on …

Aug 29, 2022 · One major phosphatase involved in this process is the phosphatase holoenzyme PP2A-B55. This review will be focused in the latest structural, biochemical and enzymatic …

In this study we identified over 100 binding proteins of B55α and B55β in Xenopus egg extracts that are involved in metabolism, mitochondria function, molecular trafficking, cell division, …

Dec 5, 2024 · In this study, we demonstrate that the Greatwall-Endosulfine-PPA/B55 pathway connects the downregulation of TORC1 with the upregulation of TORC2, resulting in the …