Cross talk between PI3K-AKT-GSK-3β and PP2A pathways
Reduction of tau phosphorylation by inhibition of GSK-3β may be more than offset by inhibition of PP2A through a shift in phosphatase methylesterase-1/leucine carboxyl methyltransferase 1 …
Protein phosphatase 2A regulates life and death decisions via Akt …
Nov 27, 2007 · The oncoprotein polyoma small T interacts with PP2A to regulate survival. In the presence of growth factors, small T induces apoptosis. Akt activity, which usually promotes …
PP2A regulates metastasis and vasculogenic mimicry formation …
Oct 1, 2022 · This study indicated that PP2A could regulate VM formation in NSCLC through the PI3K/AKT/ZEB1 axis. PP2A reactivation or combination with PI3K inhibitor might be a more …
Therapeutic Targeting of PP2A - PMC - PubMed Central (PMC)
Characterization of perphenazine using ligand affinity chromatography and mass spectrometry identified PP2A as the molecular target of this drug series. Treatment of T-ALL cells with …
Regulation of phosphorylation of Thr-308 of Akt, cell proliferation ...
Jan 25, 2008 · We found endogenous association of PP2A AB55C holoenzymes with Akt by co-immunoprecipitation analyses in pro-lymphoid FL5.12 cells. Akt was shown to associate with …
Physiological regulation of Akt activity and stability - PMC
There is evidence that PP2A targets Akt to cause cellular transformation. The PI3K-Akt signaling cascade is activated by ST of SV40 , and by repressing PP2A, ST promotes phosphorylation …
Dysregulation of PP2A-Akt interaction contributes to Sucrose non ...
Dephosphorylated PPP2R5D promotes constitutive assembly of PP2A-AKT complex, therefore inhibits insulin-induced AKT phosphorylation and subsequent glucose uptake in both BAT and …
Regulation of Phosphorylation of Thr-308 of Akt, Cell …
The PP2A-B55α Holoenzyme Preferentially Regulates the Phosphorylation of Akt at Thr-308 Downstream of IL-3 Stimulation in FL5.12 Cells—Given that the PP2A-B55α holoenzyme …
PP2A-B55: substrates and regulators in the control of cellular ...
Oct 22, 2021 · PP2A is a major serine/threonine phosphatase class involved in the regulation of cell signaling through the removal of protein phosphorylation. This class of phosphatases is …
Phosphorylation of PP2Ac by PKC is a key regulatory step in the PP2A …
Feb 28, 2024 · By replacing the phosphorylated residue with either unphosphorylatable or phosphomimetic residues (S24A and S24E), we found that this phosphorylation event is …