PP2A is a therapeutically targetable driver of cell fate decisions via ...
Mar 3, 2022 · Using OSU-2S 6,33 as a novel PP2A activator in AML in parallel with genetic approaches, we identified the PP2A-driven c-Myc/p21 axis as a critical regulator of …
A new regulatory mechanism of protein phosphatase 2A …
Jan 8, 2020 · PP2A phosphatase is a key regulator of cell homeostasis and is recurrently inactivated in AML. The anticancer activity of several PP2A-activating drugs (e.g., FTY720) …
PP2A activation targets AML stem cells | Blood | American Society …
Mar 3, 2022 · In AML stem cells, activated PP2A results in reduced expression of cMYC and subsequent induction of p21, leading to inhibition of leukemia-initiating cell proliferation and …
The Role of MYC and PP2A in the Initiation and Progression of …
By preventing PP2A-B56α interaction with MYC, CIP2A gained scientific attention, and it is now considered a promising target for tumor treatment, particularly in AML [81,96,116], where it is …
Targeting PP2A in cancer: Combination therapies - PMC
Protein Phosphatase 2A (PP2A) is a serine/threonine phosphatase with functions that counter-balance kinase-mediated phosphorylation throughout cell signaling networks. Its activity is …
Frontiers | Protein Phosphatase 2A as a Therapeutic Target in …
Apr 5, 2016 · Inactivation of the tumor-suppressor protein phosphatase 2A (PP2A) is frequent in AML patients, making it a promising target for therapy. There are several PP2A inactivating …
SET-PP2A complex as a new therapeutic target in KMT2A (MLL) rearranged AML
Oct 27, 2023 · Investigation of SET expression in acute myeloid leukemia (AML) samples demonstrated that SET is overexpressed, and elevated expression of SET is correlated with …
PP2A is a therapeutically targetable driver of cell fate
Mar 3, 2022 · Our findings identify the PP2A/c-Myc/p21 axis as a critical regulator of the differentiation/proliferation switch in AML that can be therapeutically targeted in malignancies …
Activation of the PP2A-B56α heterocomplex synergizes with
Mar 2, 2023 · Protein phosphatase 2A (PP2A) is a tumor suppressor phosphatase with pleiotropic functions that becomes inactivated in ∼70% of AML cases. PP2A promotes cancer cell death …
SET-PP2A complex as a new therapeutic target in KMT2A (MLL) rearranged AML
Oct 27, 2023 · In this study we uncover the essential role and underlying mechanisms of SET, the endogenous inhibitor of Ser/Thr phosphatase PP2A, in KMT2A-R-leukemia. Investigation of …