Oct 1, 2010 · Compounds PP2 and Ro318220, Src and PKC family inhibitors, respectively abrogated ERK2 and p38 MAPK phosphorylation by 17β-estradiol. Of interest, the hormone was able to induce Src and PKCδ activation. In addition, Ro318220 decreased estrogen-dependent Src modulation implicating PKC in hormone upregulation of Src.

Feb 28, 2024 · Our results show that the PP2A switch is induced by PKC-mediated phosphorylation of Ser24-PP2Ac and that this phosphorylation leads to apoptosis upon GqPCR induction of various cells. We propose that this mechanism may provide an unexpected way to treat some cancer types or problems in the endocrine machinery.

Jul 5, 2014 · In this study, using both pharmacological and molecular approaches, we demonstrate that AngII-induced PKD activation is mediated by protein kinase C (PKC) and Src family kinases in primary bovine adrenal glomerulosa cells …

Nov 19, 2004 · The Stimulatory Effect of PP2 Is Ras-independent—The phorbol ester tumor promoter PMA serves as a potent, non-physiological activator of PKC by acting as a mimic of diacylglycerol, an endogenous activator of PKC.

Receptor occupation commonly initiates intracellular signaling, leading to phosphorylation and activation of phospholipase Cγ (PLCγ) isoforms and activation of the Ca 2+ - and diacylglycerol (DAG)-dependent protein kinase C (PKC), followed by cell-specific responses, such as altered gene expression, bio-mediator release, integrin activation ...

Jul 8, 2011 · Moreover, PP2 potentiated YFLLRNP- and AYPGKF-induced PKC activation, indicating that SFKs downstream of G 12/13 regulate platelet responses through the negative regulation of PKC activation as well as calcium response.

Jan 23, 2006 · In this study, we investigated whether ErbB2 can activate PKC α and determined what role PKC α plays in ErbB2-mediated breast cancer cell invasion.

Mar 15, 2013 · In WT HL60, PP2 inhibits Src-family kinase (SFK) Y416 phosphorylation (LynY397), while co-treatment with RA protects phosphorylation at this site in the presence of PP2.

Feb 1, 2010 · These results suggest that stimulation of P2Y 2 and P2Y 4 receptors by ATP modulates transcription factors through PKC/MAPKs and PKC/Src pathways in MCF-7 cells. Extracellular nucleotides are important signaling molecules in both intracellular and extracellular microenvironments, and possible effectors of neoplastic transformation [1].

The Stimulatory Effect of PP2 Is Ras-independent—The phorbol ester tumor promoter PMA serves as a potent, non-physiological activator of PKC by acting as a mimic of diacylglycerol, an endogenous activator of PKC.