Three isoforms of PP1c that share ~90% amino acid sequence similarity have been identified and includes PP1cα, PP1cβ/δ and PP1cγ [6]. PP1cγ has two splice variants; PP1cγ1 (ubiquitous expression) and PP1cγ2 (testis specific expression).

The ubiquitous Ser/Thr Protein Phosphatase 1 (PP1) regulates diverse, essential cellular processes such as cell cycle progression, protein synthesis, muscle contraction, carbohydrate metabolism, transcription and neuronal signaling. However, the ...

Protein phosphatase 1 isoforms α, β, and γ (PP1α, PP1β, and PP1γ) are highly homologous in the catalytic domains but have distinct subcellular localizations. In this study, we utilized both primary cell culture and knockout mice to investigate the isoform-specific roles of PP1s in …

Jul 1, 2001 · The sequence of the catalytic core of PP1 C (residues 41–269 of the mammalian α isoform) is nearly identical for all isoforms, and shows a high degree of similarity with the corresponding fragment of the catalytic subunits of PP2A and PP2B (Refs 25, 26).

Jan 1, 2001 · The PP1-M holoenzyme consists of a heterotrimer containing PP1c (perhaps a specific isoform) [38], a large (110–130 kDa) subunit termed M 110 (also termed MYPT1) [39], and a small (21 kDa) subunit termed M20; a multienzyme form of PP1-M associated with myosin light chain kinase (MLCK) and calmodulin has also been observed [40].

The three PP1 catalytic subunits (α, β, and γ) have ~90% homology in the catalytic domains and unique N and C terminal sequences. The function of each isoform in the heart remains poorly understood. In this study, we created heart–specific PP1 …

This review will summarize how PP1 regulates phosphorylation of some of the key cardiac proteins involved in Ca 2+ handling and cardiac contraction, and the potential role of PP1 isoforms in controlling cardiac physiology and pathophysiology.

Sep 15, 2022 · Here we analyzed the expression and localization of the PP1 catalytic (PP1c) isoforms in formalin-fixed, paraffin-embedded prostate tissue samples, as well as in PCa cell lines.

Oct 21, 2021 · The regulatory circuit controlling cellular protein phosphatase-1 (PP1), an abundant group of Ser/Thr phosphatases, involves phosphorylation of PP1-specific inhibitor proteins.

Immunoblotting for PP1 isoforms in junctional and longitudinal SR fractions revealed that PP1b was most abundantly enriched in the longitudinal SR fraction among the PP1 isoforms.