Autophagy in the retinal pigment epithelium: a new vision and …
The daily autophagy demands in the RPE require precise gene regulation for the digestion and recycling of intracellular and POS components in lysosomes in response to light and stress …
Lysosomes: regulators of autophagy in the retinal pigmented epithelium ...
In the RPE, lysosomes degrade both extracellular (POS) and intracellular (autophagy) material. Recently, it has become very clear that lysosomes and mTORC1 signaling are interconnected …
Non-canonical Autophagy Promotes the Visual Cycle
Jul 7, 2013 · Phagocytosis and degradation of photoreceptor outer segments (POS) by the retinal pigment epithelium (RPE) is fundamental to vision. Autophagy is also responsible for bulk …
Autophagy and phagocytosis converge for better vision - PMC
Jan 1, 2014 · Convergence of phagocytosis, autophagy, and the visual cycle. The RPE performs 2 vital functions that support vision, phagocytosis, and the visual cycle. Phagocytosis and …
Autophagy Over The Lifespan: Using Fetal, Stem Cell, And Adult …
Dec 11, 2015 · To explore how RPE autophagy changes over the lifespan and in response to phagocytosis of photoreceptor outer segments (POS), we compared stem cell-derived RPE …
Autophagy in the retinal pigment epithelium: a new vision and
The daily autophagy demands in the RPE require precise gene regulation for the digestion and recycling of intracellular and POS components in lysosomes in response to light and stress …
Pharmacological Modulation of Photoreceptor Outer Segment …
Degradation of photoreceptor outer segments (POS) by retinal pigment epithelium (RPE) is essential for vision, and studies have implicated altered POS processing in the pathogenesis …
Noncanonical Autophagy Promotes the Visual Cycle
Jul 18, 2013 · Phagocytosis and degradation of photoreceptor outer segments (POS) by retinal pigment epithelium (RPE) is fundamental to vision. Autophagy is also responsible for bulk …
Dysregulated autophagy in the RPE is associated with increased ...
Dec 18, 2014 · To test whether the autophagy pathway plays a critical role to protect retinal pigmented epithelial (RPE) cells against oxidative stress, we exposed ARPE-19 and primary …
Noncanonical autophagy promotes the visual cycle - PubMed
Jul 18, 2013 · Phagocytosis and degradation of photoreceptor outer segments (POS) by retinal pigment epithelium (RPE) is fundamental to vision. Autophagy is also responsible for bulk …
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