Jul 17, 2023 · If you have a mutation in the POLD1 gene, this means you have a condition called Polymerase Proofreading-Associated Polyposis (PPAP) syndrome. PPAP syndrome increases …

DNA polymerase delta catalytic subunit (DPOD1) is an enzyme that is encoded in the human by the POLD1 gene, in the DNA polymerase delta complex. [5][6][7] DPOD1 is responsible for …

Mar 30, 2025 · POLD1 (DNA Polymerase Delta 1, Catalytic Subunit) is a Protein Coding gene. Diseases associated with POLD1 include Colorectal Cancer 10 and Mandibular Hypoplasia, …

Aug 14, 2020 · Germline pathogenic variants in the exonuclease domain (ED) of polymerases POLE and POLD1 predispose to adenomatous polyps, colorectal cancer (CRC), endometrial …

DNA polymerase delta 1 (POLD1), a catalytic and proofreading subunit of the DNA polymerase δ complex, performs a crucial role in DNA replication and repair processes. Recently, germline …

In this review, we focus primarily on POLD1, the catalytic subunit of Polδ, based on a number of recent studies that have emphasized key roles for this protein in human disease. We first …

The DNA polymerase delta (Pol δ) complex, comprising the POLD1, POLD2, POLD3, and POLD4 subunits, is essential for leading and lagging DNA strand synthesis [1, 2]. The catalytic POLD1 …

Jul 2, 2022 · POLE and POLD1 encode the catalytic and proofreading subunits of DNA polymerase ε and polymerase δ, and play important roles in DNA replication and proofreading. …

Apr 27, 2023 · Our studies demonstrate that POLD1 promotes the proliferation and metastasis of BLCA via MYC. Mechanistically, POLD1 stabilizes MYC in a manner independent of its’ DNA …

Polymerase (DNA directed), delta 1, catalytic subunit (POLD1) is a gene that encodes a subunit of DNA polymerase delta, a protein complex that plays a critical role in DNA replication and repair.