Feb 17, 2022 · Premature ovarian failure (POF) is a leading cause of women’s infertility without effective treatment. Here we show that intravenous injection of Ab4B19, an agonistic antibody …

Genetically modified MSCs that overexpress brain-derived neurotrophic factor (BDNF) have been shown to improve symptoms in a mouse model of Huntington's disease. These engineered …

Oct 1, 2024 · Plasma-derived exosomes miR-10a-5p can cross the BFB and target BDNF to accelerate POF through the TrkB/Akt/mTOR signaling pathway.

May 1, 2018 · Premature ovarian failure (POF) is a leading cause of women’s infertility without effective treatment. Here we show that intravenous injection of Ab4B19, an agonistic antibody …

Feb 28, 2017 · We examined the biosynthesis and post-translational processing of the brain-derived neurotrophic factor precursor (pro-BDNF) in cells infected with a pro-BDNF-encoding …

Premature ovarian failure (POF) is a leading cause of female infertility, and there are no effective treatments. Although the pathogenesis is unclear, it appears to involve dysregulated signaling …

Feb 17, 2022 · Premature ovarian failure (POF) is a leading cause of women's infertility without effective treatment. Here we show that intravenous injection of Ab4B19, an agonistic antibody …

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Oct 1, 2024 · In this study, we successfully established a rabbit model of POF and conducted in vitro and in vivo experiments that confirmed DiI-labeled Pla-Exos (exosomes derived from …

Jun 18, 2020 · Of the neurotrophins, the literature describing the expression and function of brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, neurotrophin receptor kinase …