
Mismatch repair endonuclease PMS2 - Wikipedia
PMS2 is a protective mediator of cell survival in p53-deficient cells and modulates protective DNA damage response pathways independently of p53. [16] PMS2 and MLH1 can protect cells …
About Mutations in the PMS2 Gene | Memorial Sloan Kettering ...
Jul 17, 2023 · This information explains how having a mutation in the PMS2 gene may affect you and your family.
The Changing Landscape of Lynch Syndrome due to PMS2 ...
In this review, we discuss the role of PMS2 in the MMR pathway, the evolving testing criteria used to identify variants in the PMS2 gene, the LS phenotype as well as the autosomal recessive …
PMS2 Gene Mutations (Lynch Syndrome): Risks & Options
Mar 24, 2025 · PMS2 inherited mutations (Lynch Syndrome) may affect your options for cancer prevention, detection and treatment. FORCE is here to guide you.
Pathology Outlines - PMS2
Sep 5, 2023 · The PMS2 gene (on chromosome 7) encodes an endonuclease that forms a heterodimer with MLH1 to form the MutL alpha complex which is activated upon recognition of …
PMS2-associated Lynch syndrome: Past, present and future
PMS2 is located on the short arm of chromosome 7 and spans 15 exons. Multiple regions with over 90% homology have been identified, all on chromosome 7, and these pseudogene …
PMS2 gene - MedlinePlus
The PMS2 gene provides instructions for making a protein that plays an essential role in repairing DNA. This protein helps fix errors that are made when DNA is copied (DNA replication) in …