Mar 29, 2019 · Colony-stimulating factor 1 (CSF1) controls macrophage differentiation, and here we sought to determine the effect of a CSF1 receptor inhibitor, PLX3397, on adipose tissue macrophage levels and...

Aug 21, 2019 · We designed and synthesized a highly selective brain-penetrant CSF1R inhibitor (PLX5622) allowing for extended and specific microglial elimination, preceding and during pathology development.

To study the impact of microglia on neuritic plaque development, we treated two-month-old 5XFAD mice with a selective colony stimulation factor 1 receptor (CSF1R) inhibitor, PLX3397, for a period of 3 months, resulting in a significant ablation of microglia.

In this study, we demonstrated sex-dependent differences in the microglial response to the CSF1R inhibitor PLX3397. Male mice exhibited greater microglial depletion compared to females.

In mice, a spontaneous mutation of the Csf1 gene or a knockout of its receptor Csf1r leads to macrophage deficiency in most tissues [5, 6]. CSF1R can be pharmacologically targeted by either CSF1R antibodies or inhibitors [7, 8].

Mar 25, 2022 · In a murine model of severe neuroinflammation induced by West Nile virus encephalitis (WNE), we showed PLX5622 efficiently depleted both microglia and a sub-population of border-associated macrophages in the CNS.

Therefore, we investigated the effects of 10‐day CSF1R inhibition using PLX5622 in three‐month‐old female 5xFAD mice, a stage characterized by the onset of neuroinflammation and minimal Aβ plaques. We observed ~65% microglia depletion in …

Sep 28, 2022 · In mice, PLX-R18 treatment after TBI has been shown to significantly increase survival, red blood cell counts, hemoglobin levels, and platelet counts by post-TBI day 23, and to lead to increased white blood cell counts and improved BM colony formation capabilities [18,19,20,21,22].

Feb 2, 2020 · Here we investigated the CSF1R inhibitor PLX5622 (PLX), which depletes microglia, and its effects on metabolic decline in aging in interaction with EE. PLX in combination with EE substantially improved metabolic outcomes in middle-aged …

In this report, we compared the effect of two commonly used CSF1R inhibitors, PLX5622 and PLX3397, on microglia and oligodendrocyte progenitor cell (OPC) numbers. In ex vivo cerebellar slices and adult mouse brain, both PLX compounds caused robust microglia loss; the kinetics of microglial depletion was more rapid with PLX5622.