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Pyridoxal 5′-phosphate (PLP)-dependent basic amino acid decarboxylases from the β/α-barrel-fold class (group IV) exist in most organisms and catalyze the decarboxylation of diverse substrates, essential for polyamine and lysine biosynthesis.

We found that the ultrafiltration and washing of ADC~PLP=AO-Agm inhibitory complex with buffer containing 0.1 mM PLP fully restored ADC activity (Figure 1 b) indicating that AO-Agm is a very potent, pseudo-irreversible inhibitor of ADC.

Biosynthetic arginine decarboxylase (ADC; also known as SpeA) plays an important role in the biosynthesis of polyamines from arginine in bacteria and plants. SpeA is a pyridoxal-5′-phosphate (PLP)-dependent enzyme and shares weak sequence homology with several other PLP-dependent decarboxylases.

Oct 2, 2020 · ADC is homologous to eukaryotic ornithine decarboxylase (ODC) and diaminopimelate decarboxylase (DapDC), which are fold type III PLP-dependent enzymes that contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases.

Saccharomyces cerevisiae Abz2 is a pyridoxal 5 -phosphate (PLP)-dependent lyase that converts 4-amino-4-deoxychoris-mate (ADC) to para-aminobenzoate and pyruvate.

These decarboxylases use pyridoxal 5-phosphate (PLP) as cofactor and share high sequence homology. Analysis of the activity of ADC in the presence of different amino determined that beta-alanine production from aspartate was diminished in the presence of cysteine.

Saccharomyces cerevisiae Abz2 is a pyridoxal 5′-phosphate (PLP)-dependent lyase that converts 4-amino-4-deoxychorismate (ADC) to para-aminobenzoate and pyruvate.

Saccharomyces cerevisiae Abz2 is a pyridoxal 5′-phosphate (PLP)-dependent lyase that converts 4-amino-4-deoxychorismate (ADC) to para -aminobenzoate and pyruvate.

Arginine decarboxylase (ADC) is a 70 kDa pyridoxal-5'-phosphate (PLP) dependent enzyme that controls an alternative step in the biosynthesis of polyamines in some bacteria and plants. Crystals of ADC were flash-cooled and diffracted to 3.0 A …