Typically, polyvinyl alcohol (PVA) is the most commonly used emulsifier or stabilizer to formulate PLGA microspheres. PVA is a semi-crystalline synthetic polymer, soluble in water and insoluble in other organic solvents.

The amount of surfactant plays an essential role in the emulsification-solvent evaporation process, by the protection of the droplets containing the PLGA against coalescence. 65,66 Fig. 2B illustrates the effect of PVA concentration (C PVA) on the particle size for PNP prepared by …

Dec 1, 2020 · During the preparation of PDLLA and PLGA NPs via a single emulsion method, electrosteric-like stabilization imparted by the PVA-SDS led to the formation of smaller average particle diameter (Dp) than using only PVA which provided steric stabilization.

Mar 15, 2021 · Here, we developed a tunable, stabilizer-free PLGA nanoparticle formulation capable of encapsulating plasmid DNA and demonstrated the formation of an elastin-like polymer PLGA hybrid nanoparticle with exceptional stability and biocompatibility.

Polymeric nanoparticles (PNPs) are promising drug carriers in cancer treatment. Size of the particles has a significant impact on drug loading, in vivo distribution, extravasation, intratumor diffusion and cell uptake, and thus is critical for the successful development of a …

Sep 15, 2022 · For this reason, five different systems containing polymeric particles of poly [D, L–lactic–co–glycolic acid (PLGA)] were developed to encapsulate 5-ALA based on single and double emulsions methodology.

In our hands, we find that PVA is a more effective emulsifier at much higher concentrations than TPGS (e.g. diameter of 140 nm±48, 100 mg/ml PLGA in DCM, emulsified into 2 ml 5% PVA). Characterizing nanoparticles with SEM can be challenging due to differences in equipment and imaging process.

Jul 18, 2002 · Polyvinyl alcohol (PVA) is the most commonly used emulsifier in the formulation of poly lactide and poly (d, l -lactide-co-glycolide) (PLGA) polymeric nanoparticles. A fraction of PVA remains associated with the nanoparticles despite repeated washing because PVA forms an interconnected network with the polymer at the interface.

3 days ago · Then, 200 µL of polyvinyl alcohol (PVA) solution was gradually added to the prepared 3 mL PLGA solution, using an ultrasonic bath for 1 min. This step resulted in the formation of the W 1 /Y ...

Sep 15, 2022 · The results indicated that the system formed by single emulsion containing the combination PVA-PEG presented greater stability with less influence from 5-ALA. This system is a promising candidate to successfully encapsulate 5-ALA and achieve good performance and specificity for in vitro skin cancer treatment.