The pKa Table Is Your Friend - Master Organic Chemistry
Jun 18, 2010 · In this scheme, alkyl anions are the equivalent of the royal flush – they win the proton from everything underneath them in the table. Why is pK a so important? Because …
Biosynthesis of long-chain N-acyl amide by a truncated PKS …
Here, we used genome mining strategy to characterize a cryptic PKS-C hybrid from Talaromyces wortmanii and discovered the products are reduced long-chain polyketides amidated with a …
C–N bond formation by a polyketide synthase - Nature
Mar 10, 2023 · Here, we present the cryo-EM structure of CalA3, a chain release PKS module without an ACP domain, and its structures with amidation or hydrolysis products. The domain …
Biosynthesis of Long-Chain N-Acyl Amide by a Truncated
Jan 31, 2018 · Here, we used genome mining strategy to characterize a cryptic PKS-C hybrid from Talaromyces wortmanii and discovered the products are reduced long-chain polyketides …
Polyketide and Nonribosomal Peptide Antibiotics: Modularity and ...
Mar 19, 2004 · The PKS cassettes encoding the two variants of enediyne core scaffold have been classified into two groups by polymerase chain reaction (PCR) amplification and may provide …
Structure and Mechanism of Assembly Line Polyketide Synthases
Assembly line polyketide synthases (PKSs) are remarkable biosynthetic machines with considerable potential for structure-based engineering. Several types of protein-protein …
Protein-protein interactions in polyketide synthase-nonribosomal ...
Nov 14, 2018 · Polyketide synthases (PKSs) assemble small acetic acid-type acyl building blocks into polyketides through C-C bonds, and nonribosomal peptide synthetases (NRPSs) …
Structural basis for selectivity in a highly reducing type II ... - Nature
May 4, 2020 · Highly reducing type II PKSs, represented by IgaPKS, produce polyene structures instead of the well-known aromatic skeletons. Here, we report the crystal structures of the …
Insights into a dual function amide oxidase/macrocyclase from ... - Nature
Sep 28, 2018 · As 1,3-diketones and amide functional groups are common in PK/NRP hybrid metabolites, LkcE represents a potentially valuable addition to a synthetic biology toolbox as a …
Biosynthesis of Long-Chain N-Acyl Amide by a Truncated …
Jan 23, 2018 · Here, we used genome mining strategy to characterize a cryptic PKS-C hybrid from Talaromyces wortmanii and discovered the products are reduced long-chain polyketides …
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