PKR activity is required for constitutive STAT1 tyrosine 701 phosphorylation in HLA-B27 expressing cells. Since PKR is known to regulate STAT1 activation (7, 8), we studied how inhibition of PKR affects STAT1 phosphorylation.

In this review, we provide an in-depth analysis of current knowledge of this important serine/threonine protein kinase. We summarize PKR structure and function, with particular emphasis on the impact of PKR activation on translation and …

Jan 1, 2001 · Here we report that PKR is involved in IFN- and dsRNA-signaling pathways by modulating the function of the signal transducer and activator of transcription STAT1. We also show that PKR associates with STAT1 in mouse and human cells.

Mar 15, 1997 · Here we report that PKR is involved in IFN‐ and dsRNA‐signaling pathways by modulating the function of the signal transducer and activator of transcription STAT1. We also show that PKR associates with STAT1 in mouse and human cells.

Nov 1, 2024 · We speculate that lnc_000048 may form stem-loop structure-specific binding and activate PKR by inducing its phosphorylation, leading to activation of STAT1 phosphorylation and thereby enhancing STAT1 pathway-mediated polarization of THP-1 macrophages to M1 and inflammatory factor expression.

Mar 17, 1997 · Here we report that PKR is involved in IFN- and dsRNA-signaling pathways by modulating the function of the signal transducer and activator of transcription STAT1. We also show that PKR associates with STAT1 in mouse and human cells.

Dec 25, 2001 · Here we report that the STAT1 protein is upregulated in cells lacking PKR (PKR −/–) and in cells expressing dominant negative PKR mutants. This upregulation is specific for STAT1 as increased expression is not observed for other STAT proteins.

Apr 5, 2025 · Uncontrolled activation of PKR by endogenous double-stranded RNA (dsRNA) is detrimental to cells, as it leads to global translational shutdown. ... However, the levels of STAT1 phosphorylation, as ...

Jul 15, 2009 · In this study, we investigated whether PKR could affect the post-translational modifications of STAT1 protein and whether these modifications regulate osteoblast differentiation. We demonstrated that PKR was necessary for the ubiquitination of STAT1 protein.

Mar 6, 2006 · Stat1 activity is further controlled by the eIF2α kinase PKR, which inhibits the formation of Stat1 transcriptional complexes. We set out to determine if an indirect pathway exists that controls Stat1 phosphorylation via PKR.