Protein kinase RNA-activated also known as protein kinase R (PKR), interferon-induced, double-stranded RNA-activated protein kinase, or eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) is an enzyme that in humans is encoded by the EIF2AK2 gene on chromosome 2.

Mar 30, 2025 · EIF2AK2 (Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2) is a Protein Coding gene. Diseases associated with EIF2AK2 include Dystonia 33 and Leukoencephalopathy, Developmental Delay, And Episodic Neurologic Regression Syndrome. Among its related pathways are Transport of the SLBP independent Mature mRNA and Infectious disease.

Protein kinase R (PKR) is a serine-threonine kinase (551 amino acid long) encoded in humans by the EIF2AK2 gene [located on chromosome 2 (Feng et al., 1992)], which plays a major role in central cellular processes such as mRNA translation, transcriptional control, regulation of apoptosis, and proliferation (García et al., 2007).

Among the IFN inducible gene products are the protein kinase regulated by RNA (PKR) and the adenosine deaminase acting on RNA (ADAR1). PKR is an established key player in the antiviral actions of IFN, through dsRNA-dependent activation and subsequent phosphorylation of protein synthesis initiation factor eIF2α thereby altering the ...

Jun 1, 2007 · PKR is activated in response to dsRNA of cellular, viral, or synthetic (such as polyrI:polyrC, pIC) origin, with a size greater than 30 nucleotides. PKR mediates a critical role in response to dsRNA, acting as a sensor of viral infections.

Protein kinase R (PKR) is an interferon-induced kinase that plays a key role in the innate immunity response to viral infection (Toth et al., 2006). PKR is induced in a latent form that is activated by binding dsRNA to undergo autophosphorylation and …

The most important genetic risk factor for both familial and sporadic forms of AD is the apoE4 gene [2, 3]. ApoE4 enhances the rate of amyloid fibril formation, interacts with the microtubule-associated proteins (MAPs) [4, 5] and directly affects cholinergic activity in …

Nov 30, 2008 · Protein kinase PKR (also known as EIF2AK2) is activated during viral infection and phosphorylates the α subunit of eukaryotic translation initiation factor 2 (eIF2), leading to inhibition of...

Apr 8, 2025 · E ATP bioluminescence assay in HCC1806 cells in PKR-sufficient and PKR-KO cells in control gene-KO and PACT-KO backgrounds. Values represent means ( ± SD) of 3 biological repeats.

May 29, 2024 · A striking case is given by protein kinase R (PKR), a member of the mammalian innate immune system. PKR detects viral replication within the host cell and halts protein synthesis to prevent viral replication by phosphorylating eIF2α, a component of the translation initiation machinery.