Selective depletion of plasma prekallikrein or coagulation factor …
Nov 10, 2011 · We demonstrate that selective reduction of prekallikrein (PKK), another member of the contact system, using antisense oligonucleotide (ASO) technology results in an …
Intrinsic Pathway of Coagulation and Thrombosis:
Jan 31, 2019 · In addition to serving as a critical component of the intrinsic pathway, FXII is also a central component of the contact system that includes PKK (prekallikrein) and HK (high …
Mechanism, Functions, and Diagnostic Relevance of FXII
Activation of FXII results from a conformational change induced by binding ("contact") with negatively charged surfaces. The activated serine protease FXIIa drives both the …
Plasma levels of factor XII, prekallikrein and high molecular weight ...
Introduction: The contact system proteins factor XII (FXII), prekallikrein (PK) and high molecular weight kininogen (HK) have roles in coagulation, fibrinolysis, thrombin-induced platelet …
IONIS-PKK Rx a Novel Antisense Inhibitor of Prekallikrein and
IONIS-PKK Rx is a second-generation 2'-O-(2-methoxyethyl)-modified chimeric antisense oligonucleotide, designed to bind and selectively reduce prekallikrein (PKK) mRNA in the liver.
Antisense Inhibition of Prekallikrein to Control Hereditary Angioedema
Sep 2, 2020 · In a compassionate-use pilot study, two patients with severe bradykinin-mediated angioedema were initially administered weekly subcutaneous injections of the unconjugated …
IONIS-PKK Rx a Novel Antisense Inhibitor of Prekallikrein and ...
Feb 28, 2019 · IONIS-PKKRx is a second-generation 2'-O- (2-methoxyethyl)-modified chimeric antisense oligonucleotide, designed to bind and selectively reduce prekallikrein (PKK) mRNA …
dysregulation of the contact system leading to recurrent, sometimes fatal, angioedema attacks. IONIS-PKK Rx is a second-generation 2¢-O-(2-methoxyethyl)-modified chimeric antisense …
Factor XII: a novel target for safe prevention of thrombosis and ...
Dec 1, 2015 · The results support the concept that fXII and PKK play important and perhaps nonredundant roles in pathogenic thrombus propagation, and highlight a novel, specific and …
Overexpression of Ogt reduces MNU and ENU induced
Nov 1, 2001 · As shown in Table 2, MNU increased the frequencies for mutation in FX-11-pKK in a dose-dependent manner. At a concentration of 2.5 mM, GlnV o tRNA suppressor mutations …