Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates ...
Nov 8, 2002 · We show here that phosphorylation of purified rat Nrf2 by the catalytic subunit of PKC was blocked by a synthetic peptide mimicking one of the potential PKC sites. …
Elucidation of an mTORC2-PKC-NRF2 pathway that sustains the
Aug 13, 2022 · PKC has been found to increase the abundance of Nuclear Factor Erythroid-derived 2-like 2 (Nrf2) [ref. 12,13,14,15,16,17,18], the key transcriptional factor to activate the …
Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates ...
In identifying a site-specific mutant (S40A) that abrogates PKC-catalyzed phosphorylation of Nrf2 and impairs its dissociation from Keap1, we have confirmed an essential role for PKC …
Regulation of Nrf2 by phosphorylation: Consequences for biological ...
May 20, 2021 · For example, PKC-induced phosphorylation within Neh2 and PERK-induced phosphorylation at unknown sites prevent KEAP1-mediated degradation of NRF2 to increase …
The dual roles of NRF2 in tumor prevention and progression: …
Nov 4, 2024 · Protein kinase C (PKC) phosphorylates NRF2 on Ser 40 and induces its dissociation from KEAP1 [63, 64]. Similarly, PKR-like ER kinase (PERK), which is essential for …
Phosphorylation of Nrf2 at Ser40 by Protein Kinase C in …
Nrf2 translocates to the nucleus, binds to the ARE, and activates gene expression. In this study, we demonstrate that protein kinase C (PKC) plays a significant role in the regulation of ARE …
Nrf2 signaling pathway: current status and potential therapeutic ...
Besides, protein kinase C (PKC) was shown to phosphorylate the Neh2 structural domain of Nrf2 , leading to dissociation of Nrf2 from its repressor Keap1, thus promoting the transcriptional …
Phosphorylation of Nrf2 at Ser40 by protein kinase C in response …
Nov 7, 2003 · Nrf2 translocates to the nucleus, binds to the ARE, and activates gene expression. In this study, we demonstrate that protein kinase C (PKC) plays a significant role in the …
Elucidation of an mTORC2-PKC-NRF2 pathway that sustains the …
Aug 13, 2022 · Here, we now identify the pathway in triple negative breast cancer cells that provides a sustained ATF4 response and enables their survival when encountering these …
Regulation of Nrf2 Signaling - PMC - PubMed Central (PMC)
Protein kinase C (PKC) phosphorylates Nrf2 at Ser40, promoting the dissociation of Nrf2 from Keap1, thereby leading to increased transcription of ARE-driven antioxidant genes .