During micropinocytosis of antigens in DC, diacylglycerol (DAG)-inducible PKC-δ stimulation drives NOX2 activity . During phagocytosis, members of the PKC-family are phosphorylated and activated by phagocytic receptor-mediated stimulation of SYK .

Jan 23, 2009 · Activation of Nox2-derived peroxide generation by a p47 phox-dependent mechanism appears to be a key component of the contraction elicited by PDBu promoting PKC activation in both BCA and mouse aorta.

PKC can also activate Nox2. In human monocytes and murine macrophages PI3K and PKC pathways are involved in Nox2 stimulation in response to insulin. This mechanism triggers ERK1/2, p38MAPK and NFκB, which culminates in the activation of monocytes and proliferation of macrophages . PKC-dependent Nox2 activation was also shown in coronary artery ...

NOX2 is the primary source of superoxide in primary acute myeloid leukemia (AML) cells. In these cells NOX2-dependent ROS generation promotes an increase in the uncoupling protein 2 (UCP2) and phosphorylation of AMPK, thus upregulating the expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3), a key regulatory glycolytic ...

Jun 8, 2015 · Protein kinase C (PKC) inhibitors also blocked ES-induced ROS production. Our results indicate that physiological levels of electrical stimulation induce ROS production in skeletal muscle cells through release of extracellular ATP and activation of P2Y1 receptors.

Endothelium-denuded bovine coronary arteries showed a PKC-dependent basal production of lucigenin (5 muM)-detected Nox oxidase-derived superoxide, which was stimulated fourfold by PKC activation with 10 muM phorbol 12,13-dibutyrate (PDBu).

Apr 23, 2015 · oxLDL binds platelet CD36 to stimulate tyrosine kinase– and PKC-dependent activation of NOX2 and generation of ROS. oxLDL- and hyperlipidemia-induced ROS mediate platelet desensitization to inhibitory cGMP signaling to …

Jun 8, 2015 · We hypothesized that ATP extruded from the muscle fiber increases ROS production via PKC-NOX2. Our results indicate that both electrical stimulation and extracellular ATP induced ROS production in skeletal muscle cells, …

Jun 1, 2017 · We observed that Nox2-derived reactive oxygen species via inhibition of phosphatase and tensin homolog and activation of the phosphoinositide-3-kinase (PI3K)/Akt pathway lead to activation of actin-binding protein cofilin, membrane ruffling, and macropinocytosis.

In our study, we have investigated the potential role of OAG in Ca (2) (+) influx-mediated NOX2 activity in neutrophil-like-differentiated HL-60 cells to further characterize second signals involved in the regulation of NOX2.