CaMKII and PKA-dependent phosphorylation co-regulate nuclear ...
Feb 15, 2021 · Nuclear histone deacetylase 4 (HDAC4) represses MEF2-mediated transcription, implicated in the development of heart failure. CaMKII-dependent phosphorylation drives …
- Author: Kathryn G. Helmstadter, Senka Ljubojevic-Holzer, Senka Ljubojevic-Holzer, Brent M. Wood, Khanha D. T...
- Publish Year: 2021
See results only from pubmed.ncbi.nlm.nih.govPost-translational Modificati…
HDAC4 is the most well-characterized member of the class IIa family in terms …
Mef2 is Regulated by CaMKII…
In this study, we report that endogenous HDAC4 and HDAC5 in VSM are …
The role of class IIa histone d…
HDAC4 phosphorylation enhances EC motility in wound healing assays and …
Post-translational Modifications Regulate Class IIa Histone …
HDAC4 is the most well-characterized member of the class IIa family in terms of the number of identified PTMs, which include phosphorylation, acetylation, sumoylation, and disulfide bond …
The role of class IIa histone deacetylases in regulating endothelial ...
HDAC4 phosphorylation enhances EC motility in wound healing assays and facilitates EC tube formation. In the research of tasquinimod, an orally active anti-angiogenic drug, John Isaacs et …
- Studies of PKC HDAC4
Mef2 is Regulated by CaMKIIδ2 and a HDAC4/HDAC5 …
May 5, 2012 · In this study, we report that endogenous HDAC4 and HDAC5 in VSM are activated in a Ca 2+ - and CaMKIIδ2-dependent manner. We further show that AngII-and PDGF …
- Author: Roman Ginnan, Li Yan Sun, John J. Schwarz, Harold A. Singer
- DOI: 10.1042/BJ20120152
- Publish Year: 2012
- Published: 2012/05/05
CaMKII and PKA-dependent phosphorylation co-regulate nuclear ...
Collectively, CaMKII limits nuclear localization of HDAC4, while PKA favors HDAC4 nuclear retention and S265/266 is essential for PKA-mediated regulation. These pathways thus …
- Author: Kathryn G. Helmstadter, Senka Ljubojevic-Holzer, Senka Ljubojevic-Holzer, Brent M. Wood, Khanha D. T...
- Publish Year: 2021
HDAC4, -5, -7, and -9 possess a definitive bipartite structure (31). The C terminus contains a conserved deacetylase do-main and a hydrophobic nuclear export sequence (NES), which …
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CaMKII and PKA-dependent phosphorylation co-regulate nuclear ...
CaMKII-dependent phosphorylation drives nucleus-to-cytoplasm HDAC4 shuttling, but protein kinase A (PKA) is also linked to HDAC4 translocation. However, the interplay of CaMKII and PKA in regulating adult cardiomyocyte HDAC4 translocation is unclear.
PKC inhibitors induces nuclear accumulation of HDAC4.
HDAC4, a class Ⅱ HDAC, colocalizes with α-synuclein and ubiquitin in Lewy bodies and also accumulates in the nuclei of dopaminergic neurons in PD models.
Parathyroid Hormone Regulates Histone Deacetylase (HDAC) 4 …
Aug 1, 2014 · We demonstrate that PKA-dependent phosphorylated HDAC4 is released from Runx2 bound to the MMP-13 promoter in these cells. Point mutation of Ser-740 in rHDAC4 …
MicroRNAs in Skeletal Muscle and Hints on Their …
Nov 23, 2020 · The alpha subunit of the heterotrimeric G protein complex (Gαi2) also suppresses HDAC4 via an indirect mechanism involving the protein kinase C (PKC) signaling . Importantly, HDAC4 is a direct target of several miRNAs with …
