Jul 6, 2009 · Based upon the foregoing body of research on PKC activators and HDAC inhibitors in AD and other neurodegenerative diseases, we believed that it would be valuable to design …

In this study, a series of protein kinase C (PKC) activators were investigated, some of which also exhibit histone deacetylase (HDAC) inhibitory activity, under the hypothesis that such …

Sep 8, 2006 · In this study, we investigate a possible signaling pathway required for NF-κB activation in response to the HDAC inhibitor apicidin. Treatment of HeLa cells with apicidin …

Jan 1, 2021 · Targeting HDAC inhibition via PTMs had been a fruitful strategy in treating neurological disorders, opening up HDAC as a novel therapeutic target, shifting the balance …

Here, we demonstrate that signaling by protein kinase C (PKC) is sufficient and, in some cases, necessary to drive nuclear export of class II HDAC5 in cardiomyocytes. Inhibition of PKC …

Several other HDAC-modifying enzymes have been shown to induce cardiac hypertrophy via transmission of calcium-independent signals. PKD, a downstream effector of PKC signaling, …

This describes a new receptor-independent pathway for transcriptional control. Previously described mechanisms for HDAC nuclear export include PKC, PKD, and CaM kinase II, all of …

Sep 8, 2006 · Histone deacetylase (HDAC) inhibitors are appreciated as one of promising anticancer drugs, but they exert differential responses depending on the cell type. We recently …

Jul 23, 2023 · Using C2C12 myotubes stimulated with dexamethasone (Dex) as a model of muscle atrophy, we report that protein kinase C delta (PKCδ) phosphorylation decreased at …

Sep 27, 2011 · Here, we describe a new signalling pathway that involves protein kinase C alpha (PKCα), histone deacetylase 6 (HDAC6) and beta‐catenin (β‐catenin), which is essential for …