Phospholipase C–mediated hydrolysis of PIP2 releases ERM …
These results demonstrate a new role of PLCs in rapid cytoskeletal remodeling and an additional key role of PIP2 in ERM protein biology, namely hydrolysis-mediated ERM inactivation. …
Mode of Ezrin-Membrane Interaction as a Function of PIP2 …
Ezrin, a protein of the ezrin, radixin, moesin (ERM) family, provides a regulated linkage between the plasma membrane and the cytoskeleton. The hallmark of this linkage is the activation of …
Regulation mechanism of ERM (ezrin/radixin/moesin) …
The ERM proteins, ezrin, radixin, and moesin, are involved in the actin filament/plasma membrane interaction as cross-linkers. CD44 has been identified as one of the major membrane binding …
Activation of Moesin, a Protein That Links Actin Cytoskeleton to …
May 5, 2012 · Two PIP2-binding sites have been described on the ERM protein but knowledge about them has not provided a coherent molecular mechanism for ERM protein activation. The …
Mode of Ezrin-Membrane Interaction as a Function of PIP2 …
Jun 21, 2016 · Ezrin, a protein of the ezrin, radixin, moesin (ERM) family, provides a regulated linkage between the plasma membrane and the cytoskeleton. The hallmark of this linkage is …
A phosphatidylinositol 4,5-bisphosphate redistribution-based …
Oct 15, 2018 · In this report, we found that in phagocytes, an atypical ITAM sequence in Moesin, a member of the conserved ERM (Ezrin-Radixin-Moesin) family 17, transduces such an …
Emerging role for ERM proteins in cell adhesion and migration
Initial observations showed that the association of ERM proteins with the cytoplasmic tail of the hyaluronan receptor CD44 requires PIP2 in vitro and in vivo suggesting that PIP2 binding …
Glucose-induced ERM protein activation and translocation …
Aug 24, 2010 · We show that insulin granules dynamically associate with PIP2, F-actin, and ERM proteins by live-cell time lapse confocal imaging. ERM proteins are expressed in MIN6 cells …
Phospholipase C-mediated hydrolysis of PIP2 releases ERM
Feb 9, 2009 · SDF-1-mediated inactivation of ERM proteins is blocked by phospholipase C (PLC) inhibitors. Conversely, reduction of phosphatidylinositol 4,5-bisphosphate (PIP2) levels by …
Molecular basis of PIP2-dependent conformational switching of ...
Jul 11, 2023 · PIP2 not only regulates CD44, but the binding of PIP2 to ERM is necessary for ERM activation (60). Pluhackova et al. used MD simulations to investigate how …
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