Activation of PI3K/Akt signaling by n-terminal SH2 domain ... - PubMed
An oncogenic form of p85α named p65 lacking the c-terminal SH2 domain (cSH2) has been cloned from an irradiation-induced murine thymic lymphoma and transgenic mice expressing …
SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway …
The ability of SHP-2 to regulate the PI3K/Akt pathway is suggested to result in the positive effect of SHP-2 on cell survival. Whether SHP-2 regulates insulin-like growth factor-1 (IGF-1) …
SH2 Domains: Folding, Binding and Therapeutical Approaches
SH2 (Src Homology 2) domains are among the best characterized and most studied protein-protein interaction (PPIs) modules able to bind and recognize sequences presenting a …
Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2 …
Mar 4, 2011 · Phosphoinositide 3-kinases (PI3Ks) are essential for cell growth, migration, and survival. The structure of a p110β/p85β complex identifies an inhibitory function for the C …
Regulation of CD28 binding to SH2 domains of Grb2 and PI3K by ...
Dec 15, 2022 · We found that trisubstituted carboranes efficiently increased the proliferation of T cells obtained from C57BL/6 mice. The carboranes specifically increased the binding of Grb2 …
The structural basis of PI3K cancer mutations: from mechanism to ...
Feb 1, 2014 · As a multidomain-containing protein, the regulatory subunits of PI3K (p85, p55, p50) bind to the phosphorylated pYXXM motif via their SH2 domains (Figure 1A) resulting in PI3K …
Structural dynamics of the N-terminal SH2 domain of PI3K in its …
Oct 25, 2022 · Here, we analysed the interaction between the N-terminal SH2 domain (nSH2) of the regulatory subunit in phosphoinositide 3-kinase (PI3K) and the cytoplasmic region of the T …
A Cross-Species Study of PI3K Protein-Protein Interactions
Feb 3, 2016 · Our data show that SHP2 binds directly to free p85 (not the p85/p110 PI3K heterodimer) and that a ternary complex of GAB2-SHP2-p85 impairs PI3K signaling while …
Inhibition of PI3K binding to activators by serine phosphorylation …
Aug 23, 2011 · The p85 regulatory subunit of PI3K contains Src homology-2 (SH2) domains that mediate binding to tyrosine-phosphorylated receptors or adaptor proteins to facilitate …
PI3Kβ functions as a protein kinase to promote cellular protein O ...
Apr 3, 2025 · PI3K has been successfully targeted for the clinical treatment of human cancers. 1,2 The finding that PI3Kβ not only functions as a lipid kinase regulating AKT activation but also …
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