The PI3K regulatory subunits p55 - Nature
Jun 6, 2014 · Surprisingly, we found that p55 α /p50 α localize to the nucleus where they bind to chromatin and regulate transcription of a subset of inflammatory/acute phase genes that are …
Stat3 and the PI3K regulatory subunits p55α and p50α regulate …
Given the role of Stat3 in regulating cell death and expression of the class I PI3K regulatory subunits p55α and p50α during mammary gland involution, we examined both Stat3 and …
The PI3K regulatory subunits p55α and p50α regulate cell
The phosphatidylinositol 3-kinase (PI3K) regulatory subunits p55α and p50α are coordinately transcriptionally upregulated by signal transducer and activator of transcription 3 (Stat3) at the …
Classes of phosphoinositide 3-kinases at a glance - PMC
The phosphoinositide 3-kinase (PI3K) family is important to nearly all aspects of cell and tissue biology and central to human cancer, diabetes and aging. PI3Ks are spatially regulated and …
Role of the p55-gamma subunit of PI3K in ALK-induced cell ... - PubMed
May 4, 2017 · These data support an important role for the p55γ subunit of PI3K in ALK-induced cell migration during brain development. Keywords: ALK; PI3K; RNAi; brain development; cell …
The structural basis of PI3K cancer mutations: from mechanism to ...
As a multidomain-containing protein, the regulatory subunits of PI3K (p85, p55, p50) bind to the phosphorylated pYXXM motif via their SH2 domains (Figure 1A) resulting in PI3K membrane …
Surprisingly, we found that p55a/p50a localize to the nucleus where they bind to chromatin and regulate transcription of a subset of inflammatory/acute phase genes that are also Stat3 …
Identification of PI3K regulatory subunit p55γ as a novel inhibitor …
Jan 1, 2015 · We aimed to investigate the role of p55γ, a regulatory subunit of PI3Ks, in vascular smooth muscle cell (VSMC) proliferation and neointimal formation. Methods and results: We …
P55PIK Regulates P53-Dependent Apoptosis in Cancer Cells by …
Jun 8, 2020 · Given important roles of PI3K and p53 signaling in the regulation of cell cycle, proliferation and apoptosis, p55PIK should be a promising target for cancer treatment, and …
Phospho-PI3 Kinase p85 (Tyr458)/p55 (Tyr199) Antibody
3 days ago · Polyclonal Antibody for studying PI3K p55 (Tyr199) phosphate/PI3K p85 alpha (Tyr467) phosphate/PI3K p85 beta (Tyr464) phosphate. Validated for IP, WB. Available in 3 …