Apr 1, 2019 · In summary, here we demonstrated that tumoral NOX4 recruits macrophages and induced M2 polarization via ROS/PI3K/Akt signaling-dependent various cytokine production, thus promoting NSCLC cell growth through JNK activation in …

Dec 28, 2022 · Enhanced NOX activity has been associated with aberrant activation of oncogenic cascades such as the phosphoinositide 3-kinase (PI3K) signaling pathway, which is upregulated in several malignancies. In this review, we examine the role of PI3K on the regulation of NOX-induced ROS formation in cancer.

Jun 30, 2014 · Inhibition of PI3K/Akt pathway could sufficiently block the cellular effects of NOX4 overexpression in NSCLC cells both in vitro and in vivo. Specifically, we demonstrated that PI3K/Akt pathway also positively regulated NOX4 expression via NF-κB-mediated manner.

We demonstrated the dual role of lactate, which as a metabolite increased NADPH levels by shunting glucose metabolism to the pentose phosphate pathway, and as a signaling molecule up-regulated NADPH oxidase 4 (NOX4) via activating …

Inhibition of PI3K/Akt pathway could sufficiently block the cellular effects of NOX4 overexpression in NSCLC cells both in vitro and in vivo. Specifically, we demonstrated that PI3K/Akt pathway also positively regulated NOX4 expression via NF-κB-mediated manner.

The finding that incubation of TGF- β 1 resulting in NOX4 overexpression caused significant stimulation of PI3K/AKT signaling in glioblastoma cells inspired us to investigate the connection between PI3K/AKT promotion and the tumorigenic effect of NOX4.

NOX4 also supports glutamine metabolism for GSH production via ROS/PI3K/Akt signaling, thus contributing to the oxidative adaption of these cells [98]. NOX4 silencing significantly reduces GLUT1, LDHA, and PKM2 expression, and NOX4-deficient cells display an impaired glycolytic phenotype characterized by decreased ATP production, glucose ...

Jun 27, 2021 · Moreover, TGF- β 1-induced metabolic reprogramming and EMT which modulated by NOX4/ROS were blocked when the phosphoinositide3-kinase (PI3K)/AKT/HIF-1 α signaling pathways were inhibited.

NOX4 promotes macrophage migration and M2 polarization via induction of various cytokine production in NSCLC cells through ROS/PI3K signaling To explore the mechanism for NOX4-mediated...

May 11, 2022 · NOX4-induced ROS maintains the stability of Nrf2 protein by preventing ROS-related proteasomal degradation via PI3K activation (Wu et al., 2017). Besides, NOX4-induced ROS could also elevate cytokine production via PI3K/Akt signaling-dependent manner to increase tumor-associated macrophage infiltration and exert pro-tumor function in NSCLC ...