Dec 25, 2009 · In leukocytes, diacylglycerol (DAG) regulates the small GTPase Ras through the agency of Ras guanyl releasing proteins (RasGRPs). Ras is thought to regulate phosphatidylinositol 3-kinase (PI3K). Therefore, DAG signaling is …

Results: Diacylglycerol kinase δ regulates a diacylglycerol feedback loop that promotes dephosphorylation of Akt. Conclusion: Diacylglycerol signaling limits Akt activation through PHLPP2.

Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.

Based on accumulated evidences, the PI3K/AKT signalling pathway is required for normal metabolism due to its characteristics, and its imbalance leads to the development of obesity and type 2 diabetes mellitus.

Simultaneously, BTK phosphorylates and activates PLCγ which cleaves PI-4,5-P 2 to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG is bound by PKCβ which triggers IKK signaling and NFkB-dependent transcription plus activation of Ras-Raf-MEK-ERK signaling.

Dec 25, 2009 · In leukocytes, diacylglycerol (DAG) regulates the small GTPase Ras through the agency of Ras guanyl releasing proteins (RasGRPs). Ras is thought to regulate phosphatidylinositol 3-kinase (PI3K). Therefore, DAG signaling is hypothesized to impact PI3K activity. The DAG analogue “pico” was used to activate RasGRPs in leukocyte-derived cell lines.

Dec 4, 2013 · Here, we show that phospholipase C–γ (PLC-γ) and PI3K were essential for efficient Ras and ERK activation and that analogs of diacylglycerol (DAG), the second messenger generated by PLC-γ, bypassed this requirement.

Nov 1, 2024 · One study provided a comprehensive review of the activation of the PI3K/AKT signaling pathway, its role in the pathogenesis and progression of PCa, and the therapeutic strategies targeting this pathway for PCa treatment.

Within the B cell receptor (BCR) signalosome, PI3Kδ and BTK are required for maximal signaling output, with BTK contributing to activation of phospholipase Cγ (PLCγ), which drives the formation of diacylglycerol (DAG) and inositol trisphosphate (IP 3) (Figure 1.3a).

May 1, 2018 · In vitro single molecule studies of the reconstituted pathway on lipid bilayers demonstrated the feasibility of this PKC-MARCKS-PI3K regulatory module linking Ca 2+ and PIP 3 signals in the reconstituted system.