Regulation of phosphoglycerate kinase 1 and its critical role in …
In this manuscript, we discussed the effects of the structure, function, molecular mechanisms underlying PGK1 regulation on the initiation and progression of cancer. Additionally, PGK1 is …
Hypoxia-induced acetylation of PAK1 enhances autophagy and
Here, we report that PAK1 (p21 [RAC1] activated kinase 1) is significantly upregulated and promotes GBM development. The Cancer Genome Atlas analysis suggests that the oncogenic …
Mitochondria-Translocated PGK1 Functions as a Protein Kinase to ...
Mar 3, 2016 · We demonstrate here that hypoxia, EGFR activation, and expression of K-Ras G12V and B-Raf V600E induce mitochondrial translocation of phosphoglycerate kinase 1 …
PGK1-mediated cancer progression and drug resistance - PMC
In this manuscript, we summarize the influence of PGK1 and its post-translational modifications on cancer initiation and progression. PGK1-mediated drug resistance and potential small …
Mitochondria-Translocated PGK1 Functions as a Protein Kinase …
Mar 3, 2016 · We demonstrate here that hypoxia, EGFR activation, and expression of K-Ras G12V and B-Raf V600E induce mitochondrial translocation of phosphoglycerate kinase 1 …
mcPGK1-dependent mitochondrial import of PGK1 promotes
Feb 27, 2023 · Here, we identify a mitochondria-encoded circular RNA, termed mcPGK1 (mitochondrial circRNA for translocating phosphoglycerate kinase 1), which is highly …
Molecular Pathways: Targeting P21-activated Kinase 1 Signaling in ...
The evolution of cancer cells involves deregulation of highly regulated fundamental pathways that are central to normal cellular architecture and functions. The p21-activated kinase 1 (PAK1) …
Phosphoglycerate kinase 1 (PGK1) in cancer: A promising target …
Sep 1, 2020 · Phosphoglycerate kinase 1 (PGK1) is the first critical enzyme to produce ATP in the glycolytic pathway. PGK1 is not only a metabolic enzyme but also a protein kinase, which …
The basic functions of phosphoglycerate kinase 1 and its roles in ...
Apr 5, 2022 · In this review, we focus on the basic functions of PGK1 and the relationship between PGK1 and different diseases, indicating that PGK1 has a broad application prospect …
PGK1 contributes to tumorigenesis and sorafenib resistance of …
Feb 4, 2022 · PGK1 exhibits pro-tumorigenic properties in vitro and in a xenograft tumor model by accelerating glycolysis and inducing CXCR4-mediated phosphorylation of AKT and ERK.
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