Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4) . This chemokine is released from alpha …

Sep 1, 2002 · We provide evidence that platelet factor 4 (PF4), but not the related chemokine neutrophil-activating polypeptide-2, induced highly purified human natural killer (NK) cells to …

Jan 11, 2007 · PF-4/CXCL4 is a member of the CXC chemokine family, which is mainly produced by platelets and known for its pleiotropic biological functions. Recently, the proteic product of a …

PF4 expression is positively associated with expression of collagen in fibroblasts. Meanwhile, as a chemokine, it also stimulates collagen expression via interaction with CXCR3.

Dec 15, 2023 · We used CHX inhibition to block protein synthesis and measured specific protein amount with or without CHX by flow cytometry (PGK-1, Ly6e, CD88/C5ar1) and …

In this study, we show that PF4, but not ␤ -TG/NAP-2, induces highly purified, human NK cells to synthesize bioactive IL-8. This effect is regulated at the transcriptional level, and it is not...

Aug 15, 2007 · PF4, a member of the CXC family of chemokines, is the most abundant protein in platelet α-granules and is released into the local environment following platelet activation. …

Mar 1, 2024 · Platelet factor 4 (PF4), also known as chemokine (C-X-C motif) ligand 4 (CXCL4), was the first chemokine identified with multiple biological functions. It was first discovered that …

Sep 1, 2002 · We provide evidence that platelet factor 4 (PF4), but not the related chemokine neutrophil-activating polypeptide-2, induced highly purified human natural killer (NK) cells to …

Mar 30, 2025 · PF4 (Platelet Factor 4) is a Protein Coding gene. Diseases associated with PF4 include Erythromelalgia and Essential Thrombocythemia. Among its related pathways are MIF …