Jun 29, 2018 · mPEG-PLA and PLA-PEG-PLA copolymeric nanoparticles with three different PLA to PEG ratios are synthesized and used for encapsulation of recombinant human Growth hormone (rhGH). The...

As a research focus in recent years, polyethylene glycol–polylactic acid (PEG–PLA) block copolymer and its end-group derivative nanoparticles can enhance the drug loading of hydrophobic drugs, reduce the burst effect, avoid being engulfed by phagocytes, increase the circulation time of drugs in blood, and improve bioavailability.

Jun 20, 2018 · PLA-polyethylene glycol-PLA (PLA-PEG-PLA) tri-block copolymers with different chain lengths were synthesized to emulsify the interfacial layer and improve the interfacial adhesion of PLA/PBAT blends.

Dec 15, 2016 · Copolymers of lactic and glycolic acids with poly (ethylene glycol) (PEG) provide thermo-responsive hydrogels.

Apr 22, 2019 · PEGylated polylactide (PLA) and poly (lactic-co-glycolic acid) (PLGA) copolymers are biodegradable polyesters, widely employed in the last decades for the design of drug delivery systems such as polymeric hydrogels and nanocarriers (e.g. micelles and nanoparticles).

Tri-block poly (lactide) poly(ethylene glycol) poly(lactide) (PLA–PEG–PLA) copolymers are among the most attractive nano-carriers for gene delivery into mammalian cells, due to their biocompatibility and biodegradability properties. However, the low ...

Mar 8, 2018 · Particularly, poly(ethylene glycol)–polylactide (PEG–PLA) micelles have been considered as one of the most promising platforms for drug delivery. The PEG shell effectively prevents the adsorption of proteins and phagocytes, thereby evidently extending the blood circulation period.

Feb 11, 2015 · To improve the stability of micelles and decrease the burst release behaviours of hydrophobic drugs, poly (lactic acid)/poly (ethylene glycol) (PLA/PEG) block copolymer based shell or core cross-linked micelles are successfully fabricated.

In this study “tree-shaped” copolymers of general formula mPEG- (PLA) n (n = 1, 2 or 4; mPEG = poly (ethylene glycol) monomethylether 2K or 5K Da; PLA = atactic or isotactic poly (lactide)) were synthesized to evaluate the architecture and chemical composition effect on the micelles formation and stability.

mPEG-PLA and PLA-PEG-PLA copolymeric nanoparticles with three different PLA to PEG ratios are synthesized and used for encapsulation of recombinant human Growth hormone (rhGH). The structure and composition of the synthesized copolymers were …