Jul 7, 2022 · Here, we show that genotoxic stress induces nuclear AKT activation through a p53-dependent mechanism that is distinct from the canonical membrane-localized PI3K–AKT …

Upon genotoxic stress, a nuclear PI3K binds to p53 in the non-membranous nucleoplasm to generate a p53-PI3,4,5P 3 complex, which recruits Akt and PDK1 and mTORC2 that are …

We demonstrate that (1) PDK1 is a putative downstream kinase of CDK1 as PDK1 contains an evolutionarily conserved CDK1 consensus phosphorylation site at Thr354; (2) CDK1 interacts …

Inadequate responses to traditional chemotherapeutic agents in cholangiocarcinoma (CCA) emphasize a requirement for new effective compounds for the treatment of this malignancy. …

Nov 23, 2020 · We showed that inhibition of PDK1 in senescent human dermal fibroblasts eradicates senescence hallmarks and restores entry into the cell cycle by suppressing both …

Mar 7, 2024 · PDK1 was found to be highly expressed in C2 and C4, while PDK2 and PDK3 exhibited upregulation in C4 and PDK4 demonstrated elevated expression in C3 (Fig. 10B).

Jul 18, 2013 · Our results show that NAC inhibits PDK1 expression through PPARα-mediated induction of p53 and inhibition of p65 protein expression. PPARα ligand enhances the effect of …

Jul 29, 2013 · Our study suggests that the efficiency of therapies targeting the aberrantly activated PI3K/PDK1/Akt pathway might be increased by the parallel blockade of feedback circuits. The...

May 24, 2016 · Phosphoinositide-dependent kinase 1 (PDK1) is a serine/threonine kinase of the AGC kinase group. The kinase activity of PDK1 depends on phosphatidyl inositol 3-kinase …

The study investigated the ability of UCN-01 to potentiate CPT-induced cytotoxicity in two human BC cell lines with mutated p53 gene via modulating CPT-activated S and G2 checkpoints and …