CDK1 specifically targets the phosphorylation of PDK1 and consequently the activity of PI3K/Akt and its effectors ERK and GSK3β.

The results of the present study show that ERK could be activated by PI3 kinase, PDK1, Akt, and Rac1 and that alternatively, Akt and Rac1 could be activated by MEK and ERK in MSTO-211H …

Sep 16, 2016 · CDK1 specifically targets the phosphorylation of PDK1 and consequently the activity of PI3K/Akt and its effectors ERK and GSK3β.

Mar 30, 2023 · The expression of 3-phosphoinositide-dependent protein kinase 1 (PDK1) protein in SODD knockout H1299 cells decreases distinctively, and the phosphorylated level of AKT, …

Oct 15, 2020 · Importantly, the re-expression of PDK1 in Pdk1-deficient L929 cells restored TNF-induced necroptosis and inhibited Casp8 activation (Figures 5 M, 5N, and S6 L). Thus, the …

A model can be proposed in which signal input from the ERK pathway induces phosphorylation of the hydrophobic motif of RSK2, thereby creating a binding site that recruits PDK1 for …

Jun 17, 2013 · Expression of PDK1 was suppressed in MSTO-211H cells transfected with the PDK1 siRNA (Fig. 4D), confirming knocking-down PDK1. ERK phosphorylation was …

May 1, 2024 · In this study, we explored the role of pyruvate dehydrogenase kinase 1 (PDK1) in osimertinib resistance. Patients exhibiting osimertinib resistance initially displayed elevated …

Feb 1, 2018 · This review analyzes the up-to-date knowledge supporting PDK1 involvement in altered signaling in cancer, what cancer types and subtypes would benefit from a PDK1 …

CDK1 specifically targets the phosphorylation of PDK1 and consequently the activity of PI3K/Akt and its effectors ERK and GSK3 β.