Our present finding that the PKCη/Rdx complex acts as an intracellular regulator of PDK1 activity through S135 phosphorylation supports the view that ERM proteins can play a role in …

Jan 20, 2008 · In this study, we show that PDK1 is required for phosphorylation of myosin light chain and cell motility, both on deformable gels and in vivo. Depletion of PDK1 alters the …

Aug 8, 2016 · SGK1, which is activated by PDK1, contributes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition of TSC2. Targeting either PDK1 …

Mar 1, 2022 · Acute myeloid leukemia remains difficult to treat due to strong genetic heterogeneity between and within individual patients. Here, we show that Pyruvate dehydrogenase kinase 1 …

Approximately 2,261,419 new cases of breast cancer (BC) and 684,996 BC-related deaths are estimated to occur in 2020 globally. New individualized therapeutic strategies are urgently …

Immunohistochemistry staining of PDK1 showed that the PDK1 expression in the SODD-KO xenograft tumor was remarkably lower than that of the WT ones (Figure 6F). When combined, …

Nov 14, 2000 · We used antisense oligonucleotides directed against PDK-1 expression to explore the role of PDK-1 in human glioblastoma cells (U87-MG), which express a mutant PTEN allele.

Aug 17, 2021 · Here, we demonstrate that downregulation of pyruvate dehydrogenase kinase 1 (PDK1), an enzyme of glycolytic cascade, enhances maximal respiration of cancer cells by …

PDK1 is crucial for PI3K/AKT/mTOR and Ras/MAPK cancer signaling. It phosphorylates AKT in a PIP 3 -dependent but S6K, SGK, and RSK kinases in a PIP 3 -independent manner.

An increasing amount of evidence hints at 3-phosphoinositide dependent protein kinase-1 (PDK1 or PDPK1) as an intriguing and underexplored target for cancer therapy. Several reports show …