Sep 16, 2016 · In this report, we aim to understand how CDK1 can control pluripotency by reducing CDK1 activity to a level that has no effect on cell cycle progression.

Cyclin-dependent kinase 1 (CDK1) is a stimulator of cell cycle progression and its activity is regularly enhanced in pancreatic cancer cells. Therefore, CDK1 has been proposed as a novel …

The clinical correlation among CDK1, PDK1 and β-Catenin, and the corresponding decrease in the expression levels of CDK1, PDK1 and β-Catenin demonstrated a significant, synergistic …

Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine protein kinase, and is a key …

Oct 28, 2023 · CDK1, the first identified member of the Cdk family, is conserved in all organisms and regulates the transition between the G2 phase and mitosis. The activity of CDK1 is …

Nov 30, 2020 · Class I phosphoinositide 3-kinase (PI3K) and mechanistic target of rapamycin complex 1 (mTORC1) signalling is inhibited during mitosis, so that autophagy and cap …

To examine the role of PDK1-dependent signaling in cell proliferation and control of the cell cycle, we have now investigated the effects of PDK1 deficiency in mouse embryonic fibroblasts (MEFs).

By leveraging a rapid conditional silencing system in human cell lines, we confirm that CDK1 assumes the role of G 1 -S CDK in the absence of CDK2. Unexpectedly, CDK1 deficiency …

Aug 8, 2016 · Here we show that in cancer cells resistant to PI3Kα inhibition, PDK1 blockade restores sensitivity to these therapies. SGK1, which is activated by PDK1, contributes to the …

Together, we demonstrate an essential role for the CDK1-PDK1-PI3K/Akt kinase signaling pathway in the regulation of self-renewal, differentiation, and somatic reprogramming, which …