Jun 1, 2020 · Key findings: HCN1 expression and AKT phosphorylation at the Thr308 site were significantly decreased in atrial myocytes after PDK1 knockout or inhibition; in contrast, HCN2 …

Mar 22, 2022 · Here we report that ribosomal protein S6 kinase beta 1 (S6K1), a member of AGC kinases and downstream target of mechanistic target of rapamycin complex 1 (mTORC1), …

The Akt signaling pathway or PI3K-Akt signaling pathway is a signal transduction pathway that promotes survival and growth in response to extracellular signals. Key proteins involved are …

Aug 29, 2024 · Recent discovery highlights an important regulatory step where Smurf1-mediated PDK1 neddylation through poly-Nedd8 chains is an early event for oncogenic Akt activation in …

Jul 22, 2024 · Here we unveiled an essential role of E3 ligase SMAD ubiquitylation regulatory factor 1 (Smurf1)-mediated phosphoinositide-dependent protein kinase 1 (PDK1) neddylation …

Mar 18, 2020 · We provide preclinical evidence implicating PDK1 as an active driver of IR-resistance by activation of the PI3K/AKT/mTOR signaling, up-modulation of cancer stemness …

Mar 26, 2010 · Our results suggest that mechanisms independent of membrane PtdIns could enable AKT phosphorylation by PDK1. For example, any protein or other molecules that …

Feb 1, 2018 · Furthermore PDK1 is implicated in signaling pathways frequently altered in cancer, such as PI3K/Akt, Ras/MAPK and Myc. PDK1 targeting has been proven to be effective in …

Mar 3, 2014 · PDK1 inhibition also resulted in reduced clot retraction indicating its role in outside-in signalling. These results demonstrate that PDK1 selectively phosphorylates Thr308 on Akt …

PKB/Akt binds to PIP 3 at the plasma membrane, allowing PDK1 to access and phosphorylate T308 in the “activation loop,” leading to partial PKB/Akt activation (Alessi et al. 1997).