Owing to the distribution of PDE4 in the human body, PDE4 inhibition can inhibit inflammatory responses from macrophages, DCs, Th1, Th2, and Th17 cells, increase the production of anti-inflammatory cytokines from macrophages, and interfere with the phenotype and function of …

Phosphodiesterase 4 (PDE4) enzymes catalyze cyclic adenosine monophosphate (cAMP) hydrolysis and are involved in a variety of physiological processes, including brain function, monocyte and macrophage activation, and neutrophil infiltration.

The phosphodiesterase 4 (PDE4) enzyme family plays a pivotal role in regulating levels of the second messenger cAMP. Consequently, PDE4 inhibitors have been investigated as a therapeutic strategy to enhance cAMP signaling in a broad range of diseases, including several types of cancers, as well as i …

Oct 22, 2022 · Recent studies have identified phosphodiesterase 4B (PDE4B), a member of the phosphodiesterase (PDEs) protein family, as a major cyclic AMP (cAMP) metabolizing enzyme in inflammatory cells, and the therapeutic role of PDE4B as chronic inflammation, cancer.

Phosphodiesterase 4 (PDE4) regulates cyclic adenosine monophosphate in cells and has been shown to be involved in the pathophysiology of AD, making it an attractive therapeutic target.

In this review, we illustrate that PDE4 inhibitors retain their therapeutic potential in myriad diseases, but target identification should be more precise to establish selective inhibition of disease-affected PDE4 isoforms while avoiding isoforms involved in adverse effects.

Oct 1, 2020 · The current review summarises data on the structure and localization and the role of PDE4 and PDE4Is in key molecular signalling pathways in brain. The therapeutic potential of PDE4 inhibitors in various neurological disorders and the data on the on-going clinical trials on PDE4Is for treating neurological disorders is also presented.

This review includes a brief overview of the domain structure and function of PDE4 isozymes, the role of PDE4s in inflammatory cell responses, and the potential therapeutic utility of PDE4 inhibitors in inflammatory diseases.

Nov 15, 2005 · In this review we will discuss the cellular and molecular biology of PDE4 isoforms (of which ∼20 have been characterized) and, in particular, the pivotal role that PDE4 isoforms play in achieving compartmentalized signaling in cells by interacting with various scaffold proteins.

Phosphodiesterase IV (PDE4) is an enzyme class that plays a key role in breaking down cyclic adenosine monophosphate (cAMP), a crucial intracellular messenger involved in regulating various inflammatory and anti-inflammatory processes in the body.