A phosphodiesterase-4 inhibitor, commonly referred to as a PDE4 inhibitor, is a drug used to block the degradative action of phosphodiesterase 4 (PDE4) on cyclic adenosine monophosphate (cAMP).

Jun 26, 2023 · PDE-4 inhibitors decrease pro-inflammatory mediators and cause bronchodilation by inhibiting the degradation of cAMP. Theophylline is a non-specific PDE inhibitor with weak action on phosphodiesterase enzymes and has approval for symptomatic relief of chronic obstructive pulmonary disease (COPD). [8]

Mar 4, 2025 · PDE5 inhibitors are commonly used for the treatment of erectile dysfunction and pulmonary hypertension. PDE4 inhibitors can be used to treat asthma, chronic obstructive pulmonary disease, psoriasis, atopic dermatitis, inflammatory bowel …

Understand the mechanism of action (MOA) of Otezla® (apremilast), a PDE4 inhibitor. Otezla dials down inflammatory drivers. Watch videos, review additional information, and test your knowledge of the MOA for Otezla for adults with plaque psoriasis, psoriatic arthritis, and oral ulcers in Behçet's Disease.

Owing to the distribution of PDE4 in the human body, PDE4 inhibition can inhibit inflammatory responses from macrophages, DCs, Th1, Th2, and Th17 cells, increase the production of anti-inflammatory cytokines from macrophages, and interfere with the phenotype and function of …

This review summarizes the medicinal chemistry journey in the design and development of effective PDE4 inhibitors, analyzed through chemical classes and taking into consideration structural aspects and binding properties, as well as inhibitory efficacy, PDE4 selectivity and the potential as therapeutic agents.

This review describes a new generation of oral PDE4B/D selective inhibitors under development and compares their PDE4 subtype profile with the approved PDE4 inhibitors currently used for treatment of psoriasis and atopic dermatitis.

PDE4 regulates the production of inflammatory mediators via the degradation of cyclic adenosine monophosphate (cAMP). Inhibition of PDE4 leads to increased intracellular cAMP, which activates protein kinase A (PKA).

Apr 4, 2013 · Advancements in phosphodiesterase (PDE)-targeted therapies have shown promise in recent years for treating patients with a variety of autoimmune diseases. This review summarizes the development of PDE4 inhibitors and the associated literature with a focus on treatments for autoimmune diseases.

Jun 9, 2024 · Phosphodiesterase 4 (PDE4) inhibitors are effective therapeutic agents for various inflammatory diseases. Roflumilast, apremilast, and crisaborole have been developed and approved for the treatment of chronic obstructive pulmonary …