Compare selective phosphodiesterase-4 inhibitors (PDE4). View important safety information, ratings, user reviews, popularity and more.

The following is a list of phosphodiesterase inhibitors. This list was created from the NCI Thesaurus.

A phosphodiesterase-4 inhibitor, commonly referred to as a PDE4 inhibitor, is a drug used to block the degradative action of phosphodiesterase 4 (PDE4) on cyclic adenosine monophosphate (cAMP). It is a member of the larger family of PDE inhibitors .

Compounds that specifically inhibit PHOSPHODIESTERASE 4. A non-steroidal medication used for the treatment of inflammatory conditions such as psoriasis and psoriatic arthritis. Investigated for use/treatment in chronic obstructive pulmonary disease (COPD). A non-steroidal topical medication used for the treatment of mild-moderate atopic dermatitis.

Mar 19, 2025 · Some PDE4 inhibitors help treat chronic obstructive pulmonary disease (COPD), while others help manage eczema, psoriasis, and psoriatic arthritis. These medications work by blocking the enzyme phosphodiesterase-4 (PDE4), which helps reduce inflammation in your body.

PDE-4: This type is specific to your lungs, causing muscles in your airway (especially your bronchial tubes) to constrict and tense up. PDE-5: These are in the lungs, and in the penis (for those assigned male sex at birth). Phosphodiesterase (PDE) inhibitors are …

cAMP-specific 3',5'-cyclic phosphodiesterase 4A is an enzyme that in humans is encoded by the PDE4A gene. [5][6] The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily.

There are four subtypes of PDE4, namely PDE4A–PDE4D, which are highly specific for cAMP degradation but not for cGMP. Inhibition of PDE4 results in the accumulation of intracellular cAMP and subsequently activates PKA, cyclic nucleotide-gated ion channels, and Epac1/2.

Mar 4, 2025 · The most common PDE4 inhibitors are roflumilast, apremilast, and ibudilast. Some examples of PDE3 inhibitors are cilostazol and milrinone. Nonspecific phosphodiesterase inhibitors include theophylline, aminophylline, and methylxanthine.

PDE4 inhibitors are prescribed to reduce inflammation and slow down disease progression in psoriasis, an inflammatory skin condition that can also lead to joint inflammation in many patients. Learn about the drug class, side effects, and drug names.