Jul 9, 2011 · NF-κB plays a crucial role in switching on the gene expression of a plethora of inflammatory and immune mediators, and as such is one of the master regulators of the immune response and a key target for anti-inflammatory drug design.

May 5, 2010 · Vinpocetine inhibits NF-κB–dependent inflammatory responses by directly targeting IKK, independent of its well-known action on PDE-1 activity and Ca 2+ regulation. Vinpocetine thus becomes an attractive therapeutical candidate for treating inflammatory diseases.

Feb 5, 2015 · This cell diagram shows the proposed interactions between PDE-PKA-cyclic AMP, MAPK, and NF-κB pathways in the cytoplasm and nucleus of microglia in response to TNF-α stimulation. These interactions control the proinflammatory gene program that alters microglial cell phenotype and function.

Nov 12, 2019 · The results obtained provide in vitro and in vivo evidence of the anti-inflammatory activity of the potent PDE4 inhibitor CHF6001, showing that with a topical administration that closely mimics inhalation in humans, it efficiently disrupts the NF-κB activation associated with LPS challenge, an effect that may be relevant for the prevention of ...

Nov 25, 2020 · The present review discusses how NF-κB, a master transcription factor of inflammation and immunity, is emerging as a key positive regulator of PD-L1 expression in cancer. NF-κB directly induces PD-L1 gene transcription by binding to its promoter, and it can also regulate PD-L1 post-transcriptionally through indirect pathways.

Aug 27, 2019 · Another anti-aggregation agent, cilostazol is a phosphodiesterase (PDE) 3 inhibitor indicated for treating intermittent claudication in the lower periphery. By increasing cyclic adenosine monophosphate (cAMP) levels, it exhibits vasodilator as well as anti-platelet effects .

Mar 1, 2023 · Targeting inhibition of PDE1 improved cognitive and memory impairment in vascular dementia (VaD) mice by suppressing NF- κ B transcription regulation and activating cAMP/CREB axis. 1. Introduction.

Oct 28, 2019 · Moreover, knockdown of PDE4B by specific small interfering RNA reduced the apoptosis of HT-22 cells treated with TNF-α. Taken together, our findings suggest that FCPR16 promotes the survival of neuronal cells exposed to TNF-α …

Jun 25, 2015 · Knockdown of PDE5 inhibits NO and iNOS protein expression in LPS-stimulated N9 microglia. Moreover, we observed that the nuclear factor-κB (NF-κB) transcriptionally upregulated PDE5 expression, which was inhibited by sildenafil and yonkenafil in …

May 25, 2010 · In particular, vinpocetine inhibits TNF-alpha-induced NF-kappaB activation and the subsequent induction of proinflammatory mediators in multiple cell types, including vascular smooth muscle cells, endothelial cells, macrophages, and epithelial cells.