Targeting IFNα to tumor by anti-PD-L1 creates feedforward
Nov 2, 2018 · Our data suggest that a next-generation PD-L1 antibody armed with IFNα improves tumor targeting and antigen presentation, while countering innate or T-cell-driven PD-L1 …
- Author: Yong Liang, Haidong Tang, Haidong Tang, Jingya Guo, Xiangyan Qiu, Zecheng Yang, Zhenhua Ren, Zhichen...
- Publish Year: 2018
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The IFN-γ/PD-L1 axis between T cells and tumor ... - PubMed
Oct 17, 2018 · The IFN-γ level was positively correlated with PD-L1 expression in murine glioma. Further, IFN-γ induces PD-L1 expression on primary cultured microglia, bone marrow-derived …
- Author: Jiawen Qian, Chen Wang, Bo Wang, Jiao Yang, Yuedi Wang, Feifei Luo, Junying Xu, Chujun Zhao, Ronghua...
- Publish Year: 2018
PD-L1 expression increased by IFN-γ via JAK2-STAT1 signaling and ...
The present study aimed to investigate the mechanisms underlying programmed death ligand 1 (PD-L1) regulation via the interferon-γ (IFN-γ)/janus kinase (JAK)/STAT signaling pathway, …
Synergistic effect of IFN-γ and IL-1β on PD-L1 …
In this study, we examined how cytokines induce PD-L1 expression in HCC cells. Both interferon gamma (IFN-γ) and interleukin 1 beta (IL-1β) induced PD-L1 expression, and the two cytokines enhanced PD-L1 expression in combination …
Acquired resistance to PD-L1 inhibition enhances a …
Dec 11, 2024 · Here we report an anti-PD-L1 treatment-induced secretome (PTIS) in tumor models of acquired resistance that is regulated by type I IFNs. These secretory changes can suppress activation of T cells ex vivo while …
IFN- γ from lymphocytes induces PD-L1 expression and promotes …
Mar 31, 2015 · The injection of IFN-γ into subcutaneous tumours induced PD-L1 expression and promoted tumour growth, and PD-L1 depletion completely abrogated tumour growth caused …
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IFNγ/PD-L1 Signaling Improves the Responsiveness of Anti-PD …
Programmed cell death 1 ligand 1 (PD-L1) can be upregulated in cancer cells via interferon gamma (IFNγ) in the tumor microenvironment. IFNγ/PD-L1 signaling is associated with the …
PD-L1 and IFN-γ modulate Non-Small Cell Lung Cancer (NSCLC) …
Jan 2, 2025 · In this paper, we investigated the roles of interferon-gamma (IFN-γ) signaling pathway and PD-L1 modulation in the development of HPD in advanced NSCLC undergoing …
The IFN-γ/PD-L1 axis between T cells and tumor …
Oct 17, 2018 · Our study identified the distribution of tumor-infiltrating T cells and PD-L1 expression in murine glioma model and human glioma samples. And we found that IFN-γ is an …
IFNγ induces PD-L1 overexpression by JAK2/STAT1/IRF-1
Dec 19, 2017 · PD-L1 promoter assays, chromatin immunoprecipitation, and electrophoretic mobility shift assays revealed that IFNγ-inducible PD-L1 overexpression is primarily mediated …
