A diagram depicting expression of PD-L1 positive tumor infiltrating immune cells (marked by red border) in an area of tumor cells (marked by black dotted line). The proportion of tumor area occupied by PD-L1-positive immune cells of any intensity determines the immune cell (IC) score

Schematic illustration of PD-L1 structure and the PD-1/PD-L1 engaged immune escape and immune therapy. (A) Three Main Hot Spots on the Human PD-L1 Surface. Residues from PD-1 are colored blue;...

A schematic diagram showing how PD-L1 is acetylated and deacetylated in tumor cells. PD-L1 is acetylated at Lys263 site by p300, leading to preventing the translocation of PD-L1 into the nucleus from the plasma membrane. HIP1R interacts with PD-L1 and AP2B1, resulting in clathrin-dependent endocytosis.

Schematic representation of PD-1 and anti-PD-1/PD-L1 mechanisms of action on T cell activity. Activated T cells at secondary lymphoid organs/tumour tissue (a) will upregulate the...

Nov 30, 2007 · Here we present the crystal structure of murine PD-1 in complex with human PD-L1. PD-1 and PD-L1 interact through the conserved front and side of their Ig variable (IgV) domains, as do the IgV domains of antibodies and T cell receptors.

These data provide a clearer understanding of the PD-1/PD-L1 pathway that limits an antitumor immune response and lead to the development of several anticancer drugs by blocking the...

Programmed Cell Death Protein 1 (PD-1) plays a vital role in inhibiting immune responses and promoting self-tolerance through modulating the activity of T-cells, activating apoptosis of antigen-specific T cells and inhibiting apoptosis of regulatory T cells.

Programmed cell death protein 1, also known as PD-1 and CD279, is a cell surface receptor that plays an important role in down-regulating the immune system and promoting self-tolerance by suppressing T cell inflammatory activity. In humans, it is encoded by the PDCD1 gene.

Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the adaptive arm of immune systems during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis.

Programmed cell death protein 1 (PD-1) plays an important role in subsiding immune responses and promoting self-tolerance through suppressing the activity of T cells and promoting differentiation of regulatory T cells.