Apr 24, 2023 · Both antibodies inhibited the interaction of feline PD-1 and feline PD-L1 in vitro. These inhibitory monoclonal antibodies augmented the interferon-gamma (IFN-γ) production in activated feline...

Feline PD-1 and PD-L1 expressions in stimulated lymphocytes. To investigate the expression of PD-1 and PD-L1 in feline immune cells, flow cytometry using anti-fPD-1 and fPD-L1 mAbs was performed on unstimulated and concanavalin A (Con A)-stimulated feline peripheral blood lymphocytes (PBLs).

We prepared recombinant feline PD-1, PD-L1, and PD-L2 proteins and confirmed receptor–ligand binding between PD-1 and PD-L1/PD-L2 using flow cytometry. Next, we established an anti-feline PD-L1 monoclonal antibody (clone CL1Mab-7) to analyze the expression of PD-L1.

PD-1 binds to programmed death ligand 1 (PD-L1), which is ubiquitously expressed, or to PD-L2 that is expressed in antigen-presenting cells (APCs). Following T cell receptor (TCR) recognition of cognate peptide/major histocompatibility complex (MHC), PD-1 …

SF # = static form item number; CAT # = CAT-PD item number; RK = reverse-keyed. SF scales are scored by averaging item responses within each scale. RK item responses must be reversed prior to averaging (i.e., keyed = 6 – item response).

CAT-PD Scale Descriptions Affective Lability : This scale measures the tendency to experience strong, rapid, and unpredictable shifts in emotion and mood, to have difficulty coping with both minor and major life stressors, and to act impulsively in the context of negative affect.

Aug 23, 2021 · Programmed cell death-1 (PD-1) Co-inhibitory checkpoint receptor 1 of 5 receptors within the CD28 coreceptor family [CD28, inducible T cell costimulatory (ICOS), cytotoxic T lymphocyte associated antigen 4 (CTLA4), B and T lymphocyte associated (BTLA)] that regulate the balance between T cell activation and immune tolerance

ACROBiosystems provides a comprehensive series of PD-1 related products for researchers to investigate and target the PD-1 pathway, including pre-biotinylated PD-1 pathway proteins.

Know comprehensive PD-1 protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.

Other immune checkpoint inhibitors act against a checkpoint protein called PD-1 or its partner protein PD-L1. Some tumors turn down the T cell response by producing lots of PD-L1.