PD-1/CD80+ small extracellular vesicles from immunocytes
May 8, 2024 · Here we demonstrate that PD-1 and CD80 carried on immunocyte-derived sEVs (I-sEV) induce an adaptive redistribution of PD-L1 in tumour cells. The resulting decreased cell …
PD-1 agonism by anti-CD80 inhibits T cell activation and ... - Nature
Feb 10, 2022 · By generating anti-CD80 antibodies that detach CD80 from the cis -PD-L1–CD80 duplex and enable PD-L1 to engage PD-1 in the presence of CD80, we demonstrate that the …
PD-L1-CD80 interactions are required for intracellular ... - Science
Jan 29, 2025 · We show that cis interactions between PD-L1 and CD80 are critical for promoting migration and define specific regions within these proteins necessary for migration. …
PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory
Dec 17, 2019 · Combined immunotherapy targeting the immune checkpoint receptors cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1), or CTLA-4 …
Restriction of PD-1 function by cis-PD-L1/CD80 interactions ... - Science
Apr 18, 2019 · In this study, we found that CD80 physiologically interacts with PD-L1 in cis on primary activated dendritic cells (DCs), which interferes with PD-L1/PD-1 binding and …
PD-1 agonism by anti-CD80 inhibits T cell activation and
Targeted blockade of the checkpoint molecule programmed cell death 1 (PD-1) can activate tumor-specific T cells to destroy tumors, whereas targeted potentiation of PD-1 is expected to …
Immunosuppressive effect of small extracellular vesicle PD-L1 is ...
Aug 2, 2023 · It was verified that co-expression of CD80 disrupted the binding of sEV PD-L1 to its receptor PD-1 on T cells and attenuated the immunosuppression mediated by sEV PD-L1 both …
Identification, binding, and structural characterization of single ...
Comparison of the CD80 and PD-1 binding sites on PD-L1 enabled the identification of a potential antibody binding region able to confer specificity for the inhibition of PD-1 binding only, which …
PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory …
Zhao et al. show that PD-L1 heterodimerizes with CD80, a shared ligand for CTLA-4 and CD28, to selectively weaken CD80:CTLA-4 interaction but not CD80:CD28 interaction. Thus, PD-L1 can …
PD-L1:CD80 Heterodimer Triggers CD28 While Repressing Both PD-1 …
Apr 21, 2019 · Herein, we report a molecular crosstalk in which the PD-1 ligand PD-L1 and the CTLA4 ligand CD80 heterodimerize in cis. This heterodimerization blocks both PD-L1:PD-1 …