Jun 26, 2012 · The receptor programmed death 1 (PD-1) inhibits T cell proliferation and plays a critical role in suppressing self-reactive T cells, and it also compromises antiviral and antitumor …

Oct 3, 2022 · Via downstream proteins, including 4E-BP1, STAT3, NF-κB, c-MYC, and AMPK in aberrant energy status, the PI3K/AKT/mTOR pathway can regulate PD-L1 post-transcription …

Anti-programmed death receptor 1 (PD-1) antibody is an immune checkpoint inhibitor that was developed to stimulate the immune system. In this study, the synergy of PD-1 blockade and …

Jun 6, 2012 · PD-1 suppressed SKP2 transcription by inhibiting phosphoinositide 3-kinase–Akt and Ras–mitogen-activated and extracellular signal–regulated kinase kinase …

The aim of this study was to evaluate the expression of AKT and phosphorylated AKT (p-AKT) in LUAD and its correlation with programmed death ligand-1 (PD-L1); and to analyze the factors …

Dec 5, 2024 · Upregulated PD-L1 in activated fibroblasts promotes activation of the PI3K/AKT/mTOR signaling through positive feedback. Ubiquitin-proteasome-mediated protein …

Nov 2, 2022 · PD-1 immune checkpoint blockade against inhibitory receptors such as receptor programmed cell death-1 (PD-1), has revolutionized cancer treatment. Effective immune …

In addition, interaction of PD-L1 with PD-1 induced phosphorylation of AKT and ERK, resulting in the activation of PI3K/AKT and MAPK/ERK pathways and increased MDR1/P-gp expression in …

May 9, 2021 · Here, we reported that blocking PD-1/PD-L1 interaction between MDSCs and B cells could reverse the immunosuppressive functions of PD-1 − PD-L1 + Bregs. The activation …

AKT mediated PD-L1 regulation is divided into two parts, activating β-catenin and activating the mechanistic target of rapamycin complex 1(mTORC1). β-catenin enhances PD-L1 expression …