The PC12 cell line has been used to get more information about diseases of the brain. It has been used in research of hypoxia, where acute hypoxia induces exocytosis and prolonged hypoxia can induce excessive exocytosis. PC12 cells were used to find which prion protein fragments caused neuronal dysfunction. [4]

The PC12 cell line is one of the most commonly used in neuroscience research, including studies on neurotoxicity, neuroprotection, neurosecretion, neuroinflammation, and synaptogenesis. Two types of this line are available in the ATCC collection: ...

PC-12 is a cell line that was derived from a transplantable rat pheochromocytoma. This cell line can be used in neuroscience and toxicology research.

The PC12 cell line, a classical model in neurobiology, is a neural crest-derived cell line that exhibits features of neuronal differentiation in response to NGF (Hans et al., 2001). From: Virus Research, 2005

PC-12 cell line was shown to be the preferred model in neurobiology study using biosensing devices and the analytical achievements and applicability of reported biosensing devices in PC-12 cultures for the detection of ions, neurotransmitters, and cellular events was summarized in …

PC12 cells have been widely used as a model for neural differentiation and as such they have been used to examine the effects of differentiation on exocytotic release and specifically release at varicosities.

Apr 14, 2020 · This paper aims to characterise the use of two distinct variants of PC12 cells as well as describe their differentiation and neuronal outgrowth with diverse NGF concentrations (rat or human origin) on various surfaces.

May 31, 2002 · PC12 cells continue to be an important model system by which to study how hormones, neurotransmitters, and neurotrophins initiate multiple signaling pathways that converge on specific cellular targets to execute complex processes, such as neurite extension and competence for neuronal excitability.

Jan 4, 2023 · We depict the cellular source, culture condition, differentiation methods, transfection methods, drugs inducing AD, general approaches (evaluation methods and metrics), and in vitro cellular models used in parallel with PC12 cells.

PC-12 cells, derived from rat adrenal pheochromocytoma, are a widely used model in neurobiology, offering insights into neural differentiation, neurotoxicity, and more. Here are some notable studies featuring these cells: