PBX1 - Wikipedia
Pre-B-cell leukemia transcription factor 1 is a protein that in humans is encoded by the PBX1 gene. [5] . The homologous protein in Drosophila is known as extradenticle, and causes …
Research progress of PBX1 in developmental and regenerative …
In this review, we summarize the structure of PBX1, its regulatory mechanisms involved in the development of various tissues and organs, and research targets of PBX1 in regenerative …
013085 - Strain Details - The Jackson Laboratory
013085 B6.129S- Pbx1 tm3.1Mlc /J These Pbx1 f/f mutant mice possess loxP sites flanking exon 3 of the targeted pre B-cell leukemia transcription factor 1 ( Pbx1 ) gene. This strain may be …
Comprehensive summary: the role of PBX1 in development and …
Jul 25, 2024 · PBX1 coordinates with transcriptional pathways to control aortic patterning and cardiac outflow tract (OFT) compartmentation in mice and pbx1-null embryos display abnormal …
PBX1-directed stem cell transcriptional program drives tumor ...
PBX1 regulates the balance between self-renewal and differentiation of hematopoietic stem cells and maintains proto-oncogenic transcriptional pathways in early progenitors. Its increased …
Pbx1 Regulates Self-Renewal of Long-Term Hematopoietic
May 8, 2008 · Transcriptional profiling revealed that multiple stem cell maintenance factors are perturbed in Pbx1-deficient LT-HSCs, which prematurely express a large subset of genes, …
Spindle function and Wnt pathway inhibition by PBX1 to ... - Nature
Feb 4, 2023 · In conclusion, this study suggests that PBX1 acts as a transcription factor to suppress DCDC2 expression and inhibit cell proliferation and metastasis by disrupting spindle …
Comprehensive summary: the role of PBX1 in development and …
Jul 26, 2024 · We show that PBX1 and E2A-PBX1 induce the development of highly malignant and difficult-to-treat solid and blood tumors. The development of specific drugs against their …
PBX1 PBX homeobox 1 [Homo sapiens (human)] - Gene - NCBI
Jan 4, 2025 · Title: Lupus susceptibility gene Pbx1 controls the development, stability, and function of regulatory T cells via Rtkn2 expression. Exosomal lncRNA NEAT1 Inhibits NK-Cell …
Inhibition of non-small-cell lung cancer cell proliferation by Pbx1
Aug 21, 2014 · Collectively, our data indicate that Pbx1 inhibits proliferation in lung cancer cells, suggesting a complex role for Pbx1 in modulating the proliferation of cancer cells and making …