This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction.

Poly(ADP-ribose) polymerase-2 (PARP-2) executes its biological functions via physical interaction with or PARylation of target proteins. PARP-2 is rapidly recruited to sites of DNA breakage leading to its enzymatic activation (left panel).

Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death. [1]

Poly (ADP-ribose) polymerases (PARPs) are a family of related enzymes that share the ability to catalyze the transfer of ADP-ribose to target proteins. PARPs play an important role in various cellular processes, including modulation of chromatin structure, transcription, replication, recombination, and DNA repair.

PARP-1 and PARP-2, rapidly recognizes DNA-strand breaks generated by genotoxic agents leading to their activation. Activated PARPs hydroiyse βNAD +, releasing nicotinamide (Nam) and one proton (H +) and catalyse the transfer of ADP-ribose moiety onto aminoacid residues of acceptor proteins.

Mar 30, 2025 · PARP2 (Poly (ADP-Ribose) Polymerase 2) is a Protein Coding gene. Diseases associated with PARP2 include Fallopian Tube Carcinoma and Cockayne Syndrome. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA).

Mar 1, 2021 · Here, we investigated the effects of PARP1, PARP2 and PARylation on activities of the main BER enzymes (APE1, DNA polymerase β [Polβ] and DNA ligase IIIα [LigIIIα]) in combination with BER...

May 15, 2023 · PARP2 is a member of the PARP enzyme family. Although, PARP2 plays role in DNA repair, it has regulatory roles in mitochondrial and lipid metabolism, it has pivotal role in bringing about the...

PARP inhibitors are a class of drugs that are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP), which plays a role in repairing DNA in damaged cells. Medical uses of these drugs include the treatment of heritable cancers. [1]

Feb 9, 2025 · PARP-2, but not PARP-1, is a critical component in androgen receptor (AR)-mediated transcription through interacting with the pioneer factor FOXA1 and facilitating AR recruitment to genome-wide prostate-specific enhancer regions and regulation PC growth.