Ribosomal protein S6 kinase beta-1 (S6K1), also known as p70S6 kinase (p70S6K, p70-S6K), is an enzyme (specifically, a protein kinase) that in humans is encoded by the RPS6KB1 gene. …

Recent studies have suggested that plasma p70S6K is a reliable index for the monitoring of patient response to mTOR inhibitors. Therefore, a better understanding of p70S6K and its role …

Jun 1, 2022 · Different screening strategies are used to identify novel classes of p70 S6K inhibitors. p70 S6 kinase (p70 S6K) is best known for its regulatory roles in protein synthesis …

In this review, we will discuss current findings of p70 S6K in the control of actin cytoskeleton dynamics. In addition, the potential role of p70 S6K in spermatogenesis and testicular function …

In response to mitogen stimulation, p70 S6 kinase activation up-regulates ribosomal biosynthesis and enhances the translational capacity of the cell. In Alzheimer’s disease (AD), there is a …

Feb 12, 2022 · We demonstrate that p70 ribosomal S6 kinase activity peaks in oligodendrocyte lineage cells at the time when they transition to myelinating oligodendrocytes during …

In mammalian cells, p70S6 kinase is likely to be a good candidate for the control of the autophagic signaling pathway downstream of the mammalian TOR (mTOR). In rat …

We report the crystal structures of the kinase domain of p70S6K1 bound to staurosporine in both the unphosphorylated state and in the 3′-phosphoinositide-dependent kinase-1 …

Aug 7, 2001 · Here, we purified membrane-based 70-kDa ribosomal protein S6 kinase (p70S6K) as a BAD S136-specific kinase. Rapamycin, which blocks mitochondrial-based p70S6K …

Jul 24, 2008 · Our results show for the first time the genome-wide transcriptional consequences of PI3K/mTOR pathway and RPS6KB1 inhibitions in breast cancer, suggesting novel …